Skeletal muscle HSP expression in response to immobilization and remobilization

M. Venojärvi, M. Kvist, L. Józsa, H. Kalimo, O. Hänninen, M. Atalay

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Heat shock proteins play an important regulatory role in the cellular defence. Oxidative stress is one of the factors inducing heat shock protein expression. This study tested the effects of 4 weeks of immobilization and subsequent remobilization on heat shock protein expression and oxidative stress in the lateral gastrocnemius and plantaris muscles of the rat. Active mobilization or free mobilization protocols were used for remobilization. In active mobilization, strenuous uphill treadmill running, twice a day, was started immediately after the immobilization and lasted for six days. Rats in the free mobilization group moved freely in their cages immediately after the immobilization. Expression of heat shock proteins was upregulated during the recovery from immobilization, especially in the lateral gastrocnemius muscle in the active mobilization group. However, markers of oxidative stress, such as protein carbonyls and 4-hydroxynonenal protein adducts, or activities of the antioxidant enzymes glutathione peroxidase and glutathione reductase, did not change after the immobilization and subsequent recovery. In summary, following immobilization, both intensive and spontaneous exercise upregulated the heat shock protein expressions in the lateral gastrocnemius muscle and partly in the plantaris muscle, which may contribute to the recovery from immobilization atrophy.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalInternational Journal of Sports Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Immobilization
Skeletal Muscle
Heat-Shock Proteins
Oxidative Stress
Glutathione Reductase
Glutathione Peroxidase
Running
Atrophy
Proteins
Antioxidants
Enzymes

Keywords

  • Heat shock proteins
  • Mobilization
  • Oxidative stress

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Skeletal muscle HSP expression in response to immobilization and remobilization. / Venojärvi, M.; Kvist, M.; Józsa, L.; Kalimo, H.; Hänninen, O.; Atalay, M.

In: International Journal of Sports Medicine, Vol. 28, No. 4, 04.2007, p. 281-286.

Research output: Contribution to journalArticle

Venojärvi, M. ; Kvist, M. ; Józsa, L. ; Kalimo, H. ; Hänninen, O. ; Atalay, M. / Skeletal muscle HSP expression in response to immobilization and remobilization. In: International Journal of Sports Medicine. 2007 ; Vol. 28, No. 4. pp. 281-286.
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