Size distribution of recruited alveolar volumes in airway reopening

B. Suki, A. M. Alencar, J. Tolnai, T. Asztalos, F. Peták, M. K. Sujeer, K. Patel, J. Patel, H. E. Stanley, Z. Hantos

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In 11 isolated dog lung lobes, we studied the size distribution of recruited alveolar volumes that become available for gas exchange during inflation from the collapsed state. Three catheters were wedged into 2-mm-diameter airways at total lung capacity. Small-amplitude pseudorandom pressure oscillations between 1 and 47 Hz were led into the catheters, and the input impedances of the regions subtended by the catheters were continuously recorded using a wave tube technique during inflation from -5 cmH2O transpulmonary pressure to total lung capacity. The impedance data were fit with a model to obtain regional tissue elastance (Eti) as a function of inflation. First, Eti was high and decreased in discrete jumps as more groups of alveoli were recruited. By assuming that the number of opened alveoli is inversely proportional to Eti, we calculated from the jumps in Eti the distribution of the discrete increments in the number of opened alveoli. This distribution was in good agreement with model simulations in which airways open in cascade or avalanches. Implications for mechanical ventilation may be found in these results.

Original languageEnglish
Pages (from-to)2030-2040
Number of pages11
JournalJournal of Applied Physiology
Volume89
Issue number5
Publication statusPublished - 2000

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Economic Inflation
Total Lung Capacity
Catheters
Electric Impedance
Avalanches
Pressure
Artificial Respiration
Gases
Dogs
Lung

Keywords

  • Atelectasis
  • Avalanches
  • Gas exchange
  • Lung elastance
  • Percolation
  • Power law

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Suki, B., Alencar, A. M., Tolnai, J., Asztalos, T., Peták, F., Sujeer, M. K., ... Hantos, Z. (2000). Size distribution of recruited alveolar volumes in airway reopening. Journal of Applied Physiology, 89(5), 2030-2040.

Size distribution of recruited alveolar volumes in airway reopening. / Suki, B.; Alencar, A. M.; Tolnai, J.; Asztalos, T.; Peták, F.; Sujeer, M. K.; Patel, K.; Patel, J.; Stanley, H. E.; Hantos, Z.

In: Journal of Applied Physiology, Vol. 89, No. 5, 2000, p. 2030-2040.

Research output: Contribution to journalArticle

Suki, B, Alencar, AM, Tolnai, J, Asztalos, T, Peták, F, Sujeer, MK, Patel, K, Patel, J, Stanley, HE & Hantos, Z 2000, 'Size distribution of recruited alveolar volumes in airway reopening', Journal of Applied Physiology, vol. 89, no. 5, pp. 2030-2040.
Suki B, Alencar AM, Tolnai J, Asztalos T, Peták F, Sujeer MK et al. Size distribution of recruited alveolar volumes in airway reopening. Journal of Applied Physiology. 2000;89(5):2030-2040.
Suki, B. ; Alencar, A. M. ; Tolnai, J. ; Asztalos, T. ; Peták, F. ; Sujeer, M. K. ; Patel, K. ; Patel, J. ; Stanley, H. E. ; Hantos, Z. / Size distribution of recruited alveolar volumes in airway reopening. In: Journal of Applied Physiology. 2000 ; Vol. 89, No. 5. pp. 2030-2040.
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