Basalsejtes naevus carcinoma betegség hat esete három családban.

Translated title of the contribution: Six cases of basal cell nevus carcinoma in three families

A. Kovács, E. Czeizel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Six cases of three families had basal cell nevus cacinoma syndrome of autosomal dominant inheritance. Five characteristics of this genetic disease are stressed: (1) 40% of cases had sporadic occurrence due to de novo mutations; (2) there are three phases in the manifestation of the disease: congenital abnormalities diagnosed after birth; nevoid phase during childhood with increase at adolescence; oncogen phase after the second decade; (3) symptoms have a variability and age-dependency, (4) this mutant gene can cause both congenital abnormalities and tumours; (5) these patients are very sensitive for environmental mutagens thus it is necessary to limit or to exclude UV and X-rays, cytostatic and immunosuppressive drug treatments.

Original languageHungarian
Pages (from-to)513-522
Number of pages10
JournalOrvosi Hetilap
Volume137
Issue number10
Publication statusPublished - Mar 10 1996

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Nevus
Basal Cell Carcinoma
Basal Cell Nevus Syndrome
Inborn Genetic Diseases
Mutagens
Cytostatic Agents
Immunosuppressive Agents
Carcinogens
X-Rays
Parturition
Mutation
Genes
Neoplasms
Therapeutics
Dependency (Psychology)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Basalsejtes naevus carcinoma betegség hat esete három családban. / Kovács, A.; Czeizel, E.

In: Orvosi Hetilap, Vol. 137, No. 10, 10.03.1996, p. 513-522.

Research output: Contribution to journalArticle

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