Sites of behavioral and neurochemical action of ACTH-like peptides and neurohypophyseal hormones

Tj B van Wimersma Greidanus, B. Bohus, G. Kovács, D. H G Versteeg, J. P H Burbach, D. De Wied

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In order to localize the site of action of neuropeptides in relation to their effects on behavior and memory various approaches have been used. As a result of studies using rats bearing lesions in different areas of the limbic system as well as of studies in which neuropeptides were locally applied into various areas of the brain it appeared that the limbic system (amygdala, hippocampus, septum and some thalamic areas) plays an essential role in the effect of vasopressin and ACTH and their derivatives on behavior and memory. Neurochemical studies generally indicate that changes occur in catecholamine utilization in these various limbic regions upon administration of these neuropeptides. It can be concluded that the effects of vasopressin in the terminal regions of the coeruleo-telencephalic noradrenalin system correlate with its effects on consolidation of memory. It is likely that the effects of vasopressin on other transmitter systems (e.g. dopamine in the amygdala and serotonin in the hippocampus) correspond with the effect of this neuropeptide on retrieval processes. In addition, regional differences in biotransformation of the neurohypophyseal hormones suggest that different patterns of behaviorally active fragments of these peptides may be present locally in the brain.

Original languageEnglish
Pages (from-to)453-463
Number of pages11
JournalNeuroscience and Biobehavioral Reviews
Volume7
Issue number4
DOIs
Publication statusPublished - 1983

Fingerprint

Posterior Pituitary Hormones
Peptide Hormones
Neuropeptides
Adrenocorticotropic Hormone
Vasopressins
Limbic System
Amygdala
Hippocampus
Telencephalon
Peptide Fragments
Brain
Biotransformation
Catecholamines
Dopamine
Serotonin
Norepinephrine

Keywords

  • Avoidance behavior
  • Limbic system structures
  • Neuropeptides
  • Neurotransmitters

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Sites of behavioral and neurochemical action of ACTH-like peptides and neurohypophyseal hormones. / Wimersma Greidanus, Tj B van; Bohus, B.; Kovács, G.; Versteeg, D. H G; Burbach, J. P H; De Wied, D.

In: Neuroscience and Biobehavioral Reviews, Vol. 7, No. 4, 1983, p. 453-463.

Research output: Contribution to journalArticle

Wimersma Greidanus, Tj B van ; Bohus, B. ; Kovács, G. ; Versteeg, D. H G ; Burbach, J. P H ; De Wied, D. / Sites of behavioral and neurochemical action of ACTH-like peptides and neurohypophyseal hormones. In: Neuroscience and Biobehavioral Reviews. 1983 ; Vol. 7, No. 4. pp. 453-463.
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