Helyspecifikus hatóanyagleadást biztosító rendszerek III. Nazális gyógyszerformák

Translated title of the contribution: Site-specific drug delivery systems III. Nasal drug delivery

Virág Szente, R. Zelkó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The nasal cavity has a large surface and a rich blood supplied mucosa. Drugs absorbed by blood vessels pass directly into the systemic circulation, thereby avoiding first-pass metabolism. Numbers of factors limit the intranasal absorption of drugs, especially peptide and protein drugs. These factors are the epithelial and mucus barrier, the rapid mucociliar clearance and the enzymatic activity. Increasing the residence time of the drug formulation in the nasal cavity and a period of contact with nasal mucosa, may improve drug absorption. Approaches to increase the residence time of drug formulations in the nasal cavity usually involve the use of microspheres, liposomes and bioadhesive gels.

Original languageHungarian
Pages (from-to)87-90
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume78
Issue number2
Publication statusPublished - 2008

Fingerprint

Drug Delivery Systems
Nose
Nasal Cavity
Drug Compounding
Pharmaceutical Preparations
Nasal Mucosa
Mucus
Microspheres
Liposomes
Blood Vessels
Mucous Membrane
Gels
Peptides
Proteins

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Helyspecifikus hatóanyagleadást biztosító rendszerek III. Nazális gyógyszerformák. / Szente, Virág; Zelkó, R.

In: Acta Pharmaceutica Hungarica, Vol. 78, No. 2, 2008, p. 87-90.

Research output: Contribution to journalArticle

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