Site-Selective Synthesis of 3,17-Diaryl-1,3,5,16-estratetraenes

Stefan Jopp, Peter Ehlers, Eva Frank, Erzsébet Mernyák, Gyula Schneider, János Wölfling, Alexander Villinger, Peter Langer

Research output: Contribution to journalArticle

Abstract

A straightforward, site-selective arylation of the bis(triflate) of estrone by Suzuki-Miyaura reactions has been developed. Monoarylation occurs selectively at the D-ring with good to excellent yield. Such products were exemplarily employed for the synthesis of estrones containing two different aryl substituents.

Original languageEnglish
Pages (from-to)600-604
Number of pages5
JournalSynlett
Volume30
Issue number5
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Suzuki-Miyaura reaction
  • palladium
  • site selectivity
  • steroids

ASJC Scopus subject areas

  • Organic Chemistry

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