Site of γ-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat

János Fiók, Zsuzsanna Ács, G. Makara, Sándor L. Erdö

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effect of altering γ-aminobutyric acid (GABA) activity on growth hormone (GH) secretion of freely moving chronically cannulated male rats was studied. Systemic injection of the GABA agonist muscimol (2 mg/kg i.v.) inhibited the anticipated secretory episode. Increasing brain GABA levels by γ-acetylenic-GABA (50 mg/kg i.v.) also inhibited the expected GH rise. When injected before the expected secretory episode, the GABA receptor antagonist bicuculline methiodide (2 mg/kg i.v.) triggered an early secretory peak. GABA and muscimol failed to change GH secretion by cultured anterior pituitary cells. When the somatostatin input to the stalk-median eminence region was interrupted by an anterolateral cut around the medial basal hypothalamus, the GH level was steadily increased and muscimol injections caused a prompt decrease of plasma GH levels. These results are consistent with the hypothesis that GABAergic tonic inhibition participates in the control of GH secretion and that GABA inhibits spontaneous GH release by inhibiting the secretion of a GH-releasing factor.

Original languageEnglish
Pages (from-to)510-516
Number of pages7
JournalNeuroendocrinology
Volume39
Issue number6
Publication statusPublished - 1984

Fingerprint

Aminobutyrates
gamma-Aminobutyric Acid
Growth Hormone
Muscimol
GABA Antagonists
GABA Agonists
Middle Hypothalamus
Growth Hormone-Releasing Hormone
Median Eminence
Injections
Somatostatin
Brain

Keywords

  • GRF
  • Growth hormone
  • Growth hormone releasing factor
  • Medial basal hypothalamus
  • Somatostatin
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Site of γ-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat. / Fiók, János; Ács, Zsuzsanna; Makara, G.; Erdö, Sándor L.

In: Neuroendocrinology, Vol. 39, No. 6, 1984, p. 510-516.

Research output: Contribution to journalArticle

Fiók, János ; Ács, Zsuzsanna ; Makara, G. ; Erdö, Sándor L. / Site of γ-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat. In: Neuroendocrinology. 1984 ; Vol. 39, No. 6. pp. 510-516.
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