Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma

Karl Andreas Schlegel, Robert Zimmermann, Michael Thorwarth, Friedrich Wilhelm Neukam, Boworn Klongnoi, Emeka Nkenke, Endre Felszeghy

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31 Citations (Scopus)


Objective: Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone. Use of PRP on autogenous bone and a bovine bone substitute were investigated in this split-mouth animal study. Study design: Premolars were extracted from minipigs. Each animal received sinus augmentation using a lateral approach with simultaneous insertion of 3 implants in each site. Groups were randomized using autogenous bone alone and combined with PRP or a bovine hydroxyapatite alone in combination with PRP. Results: Microradiographic findings in the autogenous group did not show significantly different rates by using autogenous bone alone or combined with PRP. Using the bovine hydroxyapatite as augmentation material only at 8 weeks, a nonsignificant effect in the PRP group could be seen. At all other observation periods, no significant influence was observed. Conclusion: No significant influence of PRP was found.

Original languageEnglish
Pages (from-to)e15-e25
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Issue number3
Publication statusPublished - Sep 1 2007


ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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