Single neonatal treatment with β-endorphin (hormonal imprinting) extremely enhances nocistatin level of cerebrospinal fluid in adult rats

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Abstract

In earlier experiments endorphin treatment of newborn rats caused the decrease of brain serotonin content, increasing aggressivity, enhanced sexual activity of females and changes in the binding capacity of uterine estrogen receptors at adult age, however nociceptin content of the cerebrospinal fluid was not changed. In the present experiment neonatal treatment of male and female rats was done with a single dose of 3 μg β-endorphin and in five months old rats the level of nociceptin antagonist nocistatin was determined by radioimmunoassay in the cerebrospinal fluid. In both genders the amount of nocistatin was one magnitude higher in the endorphin treated groups. There was also a significant difference between the male and female nocistatin level in the treated and non-treated groups alike, with the adventage of females. The results call attention to the possibility of influencing pain-tolerance for life, by the pain-provoked endorphin levels during delivery.

Original languageEnglish
Pages (from-to)1993-1997
Number of pages5
JournalLife Sciences
Volume74
Issue number16
DOIs
Publication statusPublished - Mar 5 2004

Fingerprint

Endorphins
Cerebrospinal fluid
Cerebrospinal Fluid
Rats
Pain
Therapeutics
Sexual Behavior
Estrogen Receptors
Radioimmunoassay
Brain
Serotonin
Experiments
nocistatin
Imprinting (Psychology)
nociceptin

Keywords

  • β-endorphin
  • Cerebrospinal fluid
  • Gender difference
  • Hormonal imprinting
  • Nocistatin

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Single neonatal treatment with β-endorphin (hormonal imprinting) extremely enhances nocistatin level of cerebrospinal fluid in adult rats",
abstract = "In earlier experiments endorphin treatment of newborn rats caused the decrease of brain serotonin content, increasing aggressivity, enhanced sexual activity of females and changes in the binding capacity of uterine estrogen receptors at adult age, however nociceptin content of the cerebrospinal fluid was not changed. In the present experiment neonatal treatment of male and female rats was done with a single dose of 3 μg β-endorphin and in five months old rats the level of nociceptin antagonist nocistatin was determined by radioimmunoassay in the cerebrospinal fluid. In both genders the amount of nocistatin was one magnitude higher in the endorphin treated groups. There was also a significant difference between the male and female nocistatin level in the treated and non-treated groups alike, with the adventage of females. The results call attention to the possibility of influencing pain-tolerance for life, by the pain-provoked endorphin levels during delivery.",
keywords = "β-endorphin, Cerebrospinal fluid, Gender difference, Hormonal imprinting, Nocistatin",
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T1 - Single neonatal treatment with β-endorphin (hormonal imprinting) extremely enhances nocistatin level of cerebrospinal fluid in adult rats

AU - Tekes, K.

AU - Hantos, M.

AU - Csaba, G.

PY - 2004/3/5

Y1 - 2004/3/5

N2 - In earlier experiments endorphin treatment of newborn rats caused the decrease of brain serotonin content, increasing aggressivity, enhanced sexual activity of females and changes in the binding capacity of uterine estrogen receptors at adult age, however nociceptin content of the cerebrospinal fluid was not changed. In the present experiment neonatal treatment of male and female rats was done with a single dose of 3 μg β-endorphin and in five months old rats the level of nociceptin antagonist nocistatin was determined by radioimmunoassay in the cerebrospinal fluid. In both genders the amount of nocistatin was one magnitude higher in the endorphin treated groups. There was also a significant difference between the male and female nocistatin level in the treated and non-treated groups alike, with the adventage of females. The results call attention to the possibility of influencing pain-tolerance for life, by the pain-provoked endorphin levels during delivery.

AB - In earlier experiments endorphin treatment of newborn rats caused the decrease of brain serotonin content, increasing aggressivity, enhanced sexual activity of females and changes in the binding capacity of uterine estrogen receptors at adult age, however nociceptin content of the cerebrospinal fluid was not changed. In the present experiment neonatal treatment of male and female rats was done with a single dose of 3 μg β-endorphin and in five months old rats the level of nociceptin antagonist nocistatin was determined by radioimmunoassay in the cerebrospinal fluid. In both genders the amount of nocistatin was one magnitude higher in the endorphin treated groups. There was also a significant difference between the male and female nocistatin level in the treated and non-treated groups alike, with the adventage of females. The results call attention to the possibility of influencing pain-tolerance for life, by the pain-provoked endorphin levels during delivery.

KW - β-endorphin

KW - Cerebrospinal fluid

KW - Gender difference

KW - Hormonal imprinting

KW - Nocistatin

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SN - 0024-3205

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