Single haemoglobin nanocapsules as test materials for artificial blood

Imre Hegedüs, E. Nagy, Éva Kiss-Tóth Dojcsak, Adrienn Juhászné Szalai, Zita Lovrity, János Emmer, Péter Koska, Bertalan Fodor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Single protein nanocapsules (SPNs) means that each individual protein molecules are coated with a very thin polymer layer. The polymer chains which are porous enough to allow enzymatic functions are bound covalently to the protein molecule. According to our previous results the polymer layer can essentially stabilize different types of enzymes, e.g. its stability became to 50-70 times longer than that of the native ones. The heat stability (at 80 °C SPNs has activity after 24 hours) and the pH-stability (from pH = 1.5 to pH = 12.0) of the covered enzyme can essentially be improved comparing to the native enzymes. Our results show, that SPNs have a good features as drug carriers: acrylamide-bisacrylamide copolymer layer can carries bovine serum albumin molecules across the blood brain barrier in rat brain. We synthesized single haemoglobin nanocapsules with acrylamide-bisacrylamide copolymer on the surface of the molecules (PAAHgB) and their size, homogeneity, aggregation status, zeta potential were investigated compared with other nanomaterials.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalPeriodica Polytechnica: Chemical Engineering
Volume58
Issue numberSUPPL
DOIs
Publication statusPublished - 2014

Fingerprint

Blood substitutes
Nanocapsules
Blood Substitutes
Hemoglobin
Hemoglobins
Proteins
Polymers
Molecules
Enzymes
Acrylamide
Copolymers
Drug Carriers
Zeta potential
Bovine Serum Albumin
Nanostructured materials
Rats
Brain
Agglomeration

Keywords

  • Allergic reaction
  • Artificial blood
  • Biocompatibility
  • Single haemoglobin nanocapsules

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Hegedüs, I., Nagy, E., Kiss-Tóth Dojcsak, É., Juhászné Szalai, A., Lovrity, Z., Emmer, J., ... Fodor, B. (2014). Single haemoglobin nanocapsules as test materials for artificial blood. Periodica Polytechnica: Chemical Engineering, 58(SUPPL), 11-16. https://doi.org/10.3311/PPch.7284

Single haemoglobin nanocapsules as test materials for artificial blood. / Hegedüs, Imre; Nagy, E.; Kiss-Tóth Dojcsak, Éva; Juhászné Szalai, Adrienn; Lovrity, Zita; Emmer, János; Koska, Péter; Fodor, Bertalan.

In: Periodica Polytechnica: Chemical Engineering, Vol. 58, No. SUPPL, 2014, p. 11-16.

Research output: Contribution to journalArticle

Hegedüs, I, Nagy, E, Kiss-Tóth Dojcsak, É, Juhászné Szalai, A, Lovrity, Z, Emmer, J, Koska, P & Fodor, B 2014, 'Single haemoglobin nanocapsules as test materials for artificial blood', Periodica Polytechnica: Chemical Engineering, vol. 58, no. SUPPL, pp. 11-16. https://doi.org/10.3311/PPch.7284
Hegedüs I, Nagy E, Kiss-Tóth Dojcsak É, Juhászné Szalai A, Lovrity Z, Emmer J et al. Single haemoglobin nanocapsules as test materials for artificial blood. Periodica Polytechnica: Chemical Engineering. 2014;58(SUPPL):11-16. https://doi.org/10.3311/PPch.7284
Hegedüs, Imre ; Nagy, E. ; Kiss-Tóth Dojcsak, Éva ; Juhászné Szalai, Adrienn ; Lovrity, Zita ; Emmer, János ; Koska, Péter ; Fodor, Bertalan. / Single haemoglobin nanocapsules as test materials for artificial blood. In: Periodica Polytechnica: Chemical Engineering. 2014 ; Vol. 58, No. SUPPL. pp. 11-16.
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