Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo

Darrell A. Henze, L. Wittner, György Buzsáki

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

Processing of neuronal information depends on interactions between the anatomical connectivity and cellular properties of single cells. We examined how these computational building blocks work together in the intact rat hippocampus. Single spikes in dentate granule cells, controlled intracellularly, generally failed to discharge either interneurons or CA3 pyramidal cells. In contrast, trains of spikes effectively discharged both CA3 cell types. Increasing the discharge rate of the granule cell increased the discharge probability of its target neuron and decreased the delay between the onset of a granule cell train and evoked firing in postsynaptic targets. Thus, we conclude that the granule cell to CA3 synapses are 'conditional detonators,' dependent on granule cell firing pattern. In addition, we suggest that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons. These data demonstrate how a neural circuit of the CNS may process information.

Original languageEnglish
Pages (from-to)790-795
Number of pages6
JournalNature Neuroscience
Volume5
Issue number8
DOIs
Publication statusPublished - 2002

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Pyramidal Cells
Interneurons
Automatic Data Processing
Synapses
Hippocampus
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo. / Henze, Darrell A.; Wittner, L.; Buzsáki, György.

In: Nature Neuroscience, Vol. 5, No. 8, 2002, p. 790-795.

Research output: Contribution to journalArticle

Henze, Darrell A. ; Wittner, L. ; Buzsáki, György. / Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo. In: Nature Neuroscience. 2002 ; Vol. 5, No. 8. pp. 790-795.
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