Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome

Ji Qing Chen, E. Zilahi, Gábor Papp, S. Sipka, M. Zeher

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS). Method: We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction. Results: We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients. Conclusion: This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.

Original languageEnglish
JournalInternational Journal of Rheumatic Diseases
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

MicroRNAs
Blood Cells
Cytokines
Genes
Suppressor Genes
Human Herpesvirus 4
Real-Time Polymerase Chain Reaction
Immune System
T-Lymphocytes

Keywords

  • MicroRNA-155 (miR-155)
  • Primary Sjögren's syndrome (pSS)
  • Suppressor of cytokine signaling 1 (SOCS1)

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sj{\"o}gren's syndrome",
abstract = "Aim: The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sj{\"o}gren's syndrome (pSS). Method: We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction. Results: We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients. Conclusion: This unanticipated phenomenon might be a laboratory characteristic of Sj{\"o}gren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.",
keywords = "MicroRNA-155 (miR-155), Primary Sj{\"o}gren's syndrome (pSS), Suppressor of cytokine signaling 1 (SOCS1)",
author = "Chen, {Ji Qing} and E. Zilahi and G{\'a}bor Papp and S. Sipka and M. Zeher",
year = "2015",
doi = "10.1111/1756-185X.12804",
language = "English",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome

AU - Chen, Ji Qing

AU - Zilahi, E.

AU - Papp, Gábor

AU - Sipka, S.

AU - Zeher, M.

PY - 2015

Y1 - 2015

N2 - Aim: The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS). Method: We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction. Results: We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients. Conclusion: This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.

AB - Aim: The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS). Method: We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction. Results: We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients. Conclusion: This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.

KW - MicroRNA-155 (miR-155)

KW - Primary Sjögren's syndrome (pSS)

KW - Suppressor of cytokine signaling 1 (SOCS1)

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