Simultaneous recordings of the monophasic action potential with silver chloride- and Ir-coated electrodes

B. Merkely, V. Lang, L. Gellér, J. P. Strobel, O. Kiss, L. Fazekas, T. Vecsey, F. Horkay, A. Juhász-Nagy, M. Schaldach

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ag/AgCl and Ir-coated electrodes allow the recording of the monophasic action potential (MAP) due to their electrical properties like non- polarisability. This study investigates the correlation of MAP recorded with both types of electrodes. In 20 mongrel dogs (18 ±6 kg) an Ag/AgCl and an Ir-coated catheter (Ir) were placed endocardially in the apex of the right ventricle. The effects of isoproterenol and verapamil were investigated during spontaneous rhythm and stimulation simultaneously recorded with both types of electrodes in 10 dogs without AV-node ablation. The correlation at different heart rates were investigated in 10 other dogs with complete AV- block. The morphology and amplitudes of MAP were comparable (AgCl: 15 ± 7 mV; Ir: 13 ± 8 mV). Following an i.v. bolus of 2 κg/kg isoproterenol the spontaneous rate increased (175 ± 18 to 245 ± 25 bpm). During stimulation with 250 ms cycle length the duration shortened (MAPd90: AgCl: 160 ±11 to 130 ± 12 ms; Ir: 154 ± 18 to 128 ± 15 ms). The alterations reversed after 20 min. An i.v. bolus of 0.2 mg/kg verapamil decreased the spontaneous rate (167 ± 11 to 104 ± 23 bpm) and lengthened the MAPd90 (AgCl: 182 ± 14 to 220 ± 13 ms; Ir: 174 ± 16 to 216 ± 21 ms) at 300 ms stimulation. The correlation between the MAPd90 of both lead types was r=0.98 during all measurements. Under the effect of beta-agonist and Ca2+-antagonist medication MAP showed a strong correlation recorded with both types of electrodes. Thus, both leads allow the recording of MAP but only the Ir- electrodes with their long-term stability are implantable and allows us to control the effects of drugs with implantable devices.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalPACE - Pacing and Clinical Electrophysiology
Volume21
Issue number1 II SUPPL.
DOIs
Publication statusPublished - 1998

Fingerprint

Action Potentials
Electrodes
Dogs
Verapamil
Isoproterenol
Atrioventricular Node
Atrioventricular Block
Drug and Narcotic Control
Heart Ventricles
Catheters
Heart Rate
silver chloride
Equipment and Supplies

Keywords

  • Isoproterenol
  • Monophasic action potential
  • Pacemaker lead
  • Verapamil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Simultaneous recordings of the monophasic action potential with silver chloride- and Ir-coated electrodes. / Merkely, B.; Lang, V.; Gellér, L.; Strobel, J. P.; Kiss, O.; Fazekas, L.; Vecsey, T.; Horkay, F.; Juhász-Nagy, A.; Schaldach, M.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 21, No. 1 II SUPPL., 1998, p. 231-234.

Research output: Contribution to journalArticle

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AU - Kiss, O.

AU - Fazekas, L.

AU - Vecsey, T.

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AU - Juhász-Nagy, A.

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