Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben

Translated title of the contribution: Simultaneous presence of GIST and MALT-lymphoma of the stomach in a Helicobacter pylori negative patient

Ferenc Kovács, Tibor Gyökeres, Imre Géza Takács, István Padányi, Csaba Fekete, Zsolt Orosz, A. Pap

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - The simultaneous presence of gastric mucosa-associated lymphoid tissue lymphoma (MALT) and a gastrointestinal stromal tumor (GIST) is an extremely rare finding that has not been published until now. CASE REPORT - The authors report on a 78-year-old man who was referred to their department with an emergency upper gastrointestinal bleeding. Urgent gastroscopy revealed a bleeding ulcer in the middle third of the stomach. On the follow-up endoscopy 6 weeks later, an umbilicated polypoid lesion was found proximal to the healed ulcer, which was subsequently removed by elective surgery. Histology and immunohistochemical staining of the specimen for c-Kit confirmed the diagnosis of gastrointestinal stromal tumour. A few weeks later the patient was readmitted because of haematemesis. Upon detailed histological examination of the biopsy specimens taken from the multiple superficial ulcers found near the previous lesion, MALT-lymphoma was diagnosed. The absence of Helicobacter pylori was confirmed by repeated histological examinations, serology and urea breath test. CONCLUSION - This is the first report on a patient with simultaneous presence of a gastrointestinal stromal tumour and gastric mucosa-associated lymphoid tissue lymphoma with H. pylori negativity. Several observations suggest that the development of malignant tumours of the stomach is also associated with H. pylori infection. In view of the reported case, the possibility of a common aetiology of these two neoplasms other than H. pylori infection is discussed.

Original languageHungarian
Pages (from-to)855-859
Number of pages5
JournalLege Artis Medicinae
Volume16
Issue number10
Publication statusPublished - Oct 2006

Fingerprint

Marginal Zone B-Cell Lymphoma
Gastrointestinal Stromal Tumors
Helicobacter pylori
Lymphoma
Stomach
Ulcer
Helicobacter Infections
Gastric Mucosa
Hemorrhage
Hematemesis
Gastroscopy
Breath Tests
Serology
Endoscopy
Urea
Hospital Emergency Service
Neoplasms
Histology
Staining and Labeling
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kovács, F., Gyökeres, T., Takács, I. G., Padányi, I., Fekete, C., Orosz, Z., & Pap, A. (2006). Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben. Lege Artis Medicinae, 16(10), 855-859.

Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben. / Kovács, Ferenc; Gyökeres, Tibor; Takács, Imre Géza; Padányi, István; Fekete, Csaba; Orosz, Zsolt; Pap, A.

In: Lege Artis Medicinae, Vol. 16, No. 10, 10.2006, p. 855-859.

Research output: Contribution to journalArticle

Kovács, F, Gyökeres, T, Takács, IG, Padányi, I, Fekete, C, Orosz, Z & Pap, A 2006, 'Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben', Lege Artis Medicinae, vol. 16, no. 10, pp. 855-859.
Kovács F, Gyökeres T, Takács IG, Padányi I, Fekete C, Orosz Z et al. Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben. Lege Artis Medicinae. 2006 Oct;16(10):855-859.
Kovács, Ferenc ; Gyökeres, Tibor ; Takács, Imre Géza ; Padányi, István ; Fekete, Csaba ; Orosz, Zsolt ; Pap, A. / Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben. In: Lege Artis Medicinae. 2006 ; Vol. 16, No. 10. pp. 855-859.
@article{090017f7a9014e57a98109d85decab99,
title = "Gastrointestinalis stromatumor {\'e}s MALT-lymphoma egy{\"u}ttes elofordul{\'a}sa Helicobacter pylori-negat{\'i}v betegben",
abstract = "INTRODUCTION - The simultaneous presence of gastric mucosa-associated lymphoid tissue lymphoma (MALT) and a gastrointestinal stromal tumor (GIST) is an extremely rare finding that has not been published until now. CASE REPORT - The authors report on a 78-year-old man who was referred to their department with an emergency upper gastrointestinal bleeding. Urgent gastroscopy revealed a bleeding ulcer in the middle third of the stomach. On the follow-up endoscopy 6 weeks later, an umbilicated polypoid lesion was found proximal to the healed ulcer, which was subsequently removed by elective surgery. Histology and immunohistochemical staining of the specimen for c-Kit confirmed the diagnosis of gastrointestinal stromal tumour. A few weeks later the patient was readmitted because of haematemesis. Upon detailed histological examination of the biopsy specimens taken from the multiple superficial ulcers found near the previous lesion, MALT-lymphoma was diagnosed. The absence of Helicobacter pylori was confirmed by repeated histological examinations, serology and urea breath test. CONCLUSION - This is the first report on a patient with simultaneous presence of a gastrointestinal stromal tumour and gastric mucosa-associated lymphoid tissue lymphoma with H. pylori negativity. Several observations suggest that the development of malignant tumours of the stomach is also associated with H. pylori infection. In view of the reported case, the possibility of a common aetiology of these two neoplasms other than H. pylori infection is discussed.",
keywords = "Gastrointestinal stromal tumour, Helicobacter pylori, Mucosa associated lymphoid tissue lymphoma",
author = "Ferenc Kov{\'a}cs and Tibor Gy{\"o}keres and Tak{\'a}cs, {Imre G{\'e}za} and Istv{\'a}n Pad{\'a}nyi and Csaba Fekete and Zsolt Orosz and A. Pap",
year = "2006",
month = "10",
language = "Hungarian",
volume = "16",
pages = "855--859",
journal = "Lege Artis Medicinae",
issn = "0866-4811",
publisher = "Literatura Medica Publishing House",
number = "10",

}

TY - JOUR

T1 - Gastrointestinalis stromatumor és MALT-lymphoma együttes elofordulása Helicobacter pylori-negatív betegben

AU - Kovács, Ferenc

AU - Gyökeres, Tibor

AU - Takács, Imre Géza

AU - Padányi, István

AU - Fekete, Csaba

AU - Orosz, Zsolt

AU - Pap, A.

PY - 2006/10

Y1 - 2006/10

N2 - INTRODUCTION - The simultaneous presence of gastric mucosa-associated lymphoid tissue lymphoma (MALT) and a gastrointestinal stromal tumor (GIST) is an extremely rare finding that has not been published until now. CASE REPORT - The authors report on a 78-year-old man who was referred to their department with an emergency upper gastrointestinal bleeding. Urgent gastroscopy revealed a bleeding ulcer in the middle third of the stomach. On the follow-up endoscopy 6 weeks later, an umbilicated polypoid lesion was found proximal to the healed ulcer, which was subsequently removed by elective surgery. Histology and immunohistochemical staining of the specimen for c-Kit confirmed the diagnosis of gastrointestinal stromal tumour. A few weeks later the patient was readmitted because of haematemesis. Upon detailed histological examination of the biopsy specimens taken from the multiple superficial ulcers found near the previous lesion, MALT-lymphoma was diagnosed. The absence of Helicobacter pylori was confirmed by repeated histological examinations, serology and urea breath test. CONCLUSION - This is the first report on a patient with simultaneous presence of a gastrointestinal stromal tumour and gastric mucosa-associated lymphoid tissue lymphoma with H. pylori negativity. Several observations suggest that the development of malignant tumours of the stomach is also associated with H. pylori infection. In view of the reported case, the possibility of a common aetiology of these two neoplasms other than H. pylori infection is discussed.

AB - INTRODUCTION - The simultaneous presence of gastric mucosa-associated lymphoid tissue lymphoma (MALT) and a gastrointestinal stromal tumor (GIST) is an extremely rare finding that has not been published until now. CASE REPORT - The authors report on a 78-year-old man who was referred to their department with an emergency upper gastrointestinal bleeding. Urgent gastroscopy revealed a bleeding ulcer in the middle third of the stomach. On the follow-up endoscopy 6 weeks later, an umbilicated polypoid lesion was found proximal to the healed ulcer, which was subsequently removed by elective surgery. Histology and immunohistochemical staining of the specimen for c-Kit confirmed the diagnosis of gastrointestinal stromal tumour. A few weeks later the patient was readmitted because of haematemesis. Upon detailed histological examination of the biopsy specimens taken from the multiple superficial ulcers found near the previous lesion, MALT-lymphoma was diagnosed. The absence of Helicobacter pylori was confirmed by repeated histological examinations, serology and urea breath test. CONCLUSION - This is the first report on a patient with simultaneous presence of a gastrointestinal stromal tumour and gastric mucosa-associated lymphoid tissue lymphoma with H. pylori negativity. Several observations suggest that the development of malignant tumours of the stomach is also associated with H. pylori infection. In view of the reported case, the possibility of a common aetiology of these two neoplasms other than H. pylori infection is discussed.

KW - Gastrointestinal stromal tumour

KW - Helicobacter pylori

KW - Mucosa associated lymphoid tissue lymphoma

UR - http://www.scopus.com/inward/record.url?scp=33750523042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750523042&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 855

EP - 859

JO - Lege Artis Medicinae

JF - Lege Artis Medicinae

SN - 0866-4811

IS - 10

ER -