Persistáló haematuria (vékony-basalis-membran-nephropathia) és könnyülánc-proteinuria (benignus monoclonalis gammopathia) együttes elöfordulása egy középkorú férfiban.

Translated title of the contribution: Simultaneous occurrence of persistent hematuria (thin basement membrane nephropathy) and light-chain proteinuria (benign monoclonal gammopathy) in a middle-aged male

B. Iványi, G. Mohácsi, S. Sonkodi, J. Ormos

Research output: Contribution to journalArticle

Abstract

IgG lambda type of monoclonal gammopathy and thin basement membrane nephropathy were established in a middle-aged man examined because of persistent haematuria, lambda light-chain proteinuria and moderately diminished renal function. A 10% level of plasmocytosis was verified by bone-marrow aspiration. The more than 6-year follow-up showed the gammopathy to be benign. The thin basement membrane nephropathy was verified by electronmicroscopic analysis of renal tissue obtained by percutaneous renal biopsy: lamina densa of the glomerular capillaries thinned to 30-100 nm. In spite of the usually good outcome of thin basement membrane nephropathy, in this case it was accompanied by glomerular sclerosis, subsequent destruction of nephrons, hypertensive vascular alterations and a clinical deterioration of the renal function after 4 years. A rebiopsy excluded the possible complications (amyloidosis, non-amyloid immunoglobulin nephropathy, cylinder nephropathy, etc) of light-chain proteinuria.

Original languageHungarian
Pages (from-to)2431-2434
Number of pages4
JournalOrvosi hetilap
Volume133
Issue number38
Publication statusPublished - Sep 20 1992

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ASJC Scopus subject areas

  • Medicine(all)

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