The lipophilicity (hydrophobicity) of some alkylamines and arylamines was determined with reversed-phase thin-layer chromatography using various water: methanol mixtures as eluent with and without adding salt to the system. The effect of various structural parameters of amines and that of the chromatographic conditions were assessed with stepwise regression analysis. The calculation proved that in case of alkylamines the lipophilicity does not depend linearly on the length of the alkyl chain, the effect of methanol and salt concentrations are intercorrelated and the influence of the alkyl chain branching is negligible. In case of arylamines the number of amino groups has the highest impact on the retention and the effect of methanol and salt is also intercorrelated.
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