Simultaneous effect of organic modifier and physicochemical parameters of barbiturates on their retention on a narrow-bore PGC Column. Part 2

Tibor Cserháti, Maria Szögyi

Research output: Contribution to journalArticle


The retention time of 23 barbituric acid derivatives was determined on an narrow-bore porous graphitized carbon (PGC) column employing water-dioxane mixtures as mobile phases. The retention fac-tor (k), theoretical plate number (N), and asymmetry factor (AF) were computed for each analyte in each mobile phase. Quantitative structure-retention relationship (QSRR) calculations using stepwise regression analysis (SRA) demonstrated the binding of analytes to the surface of PGC stationary phase is influenced by electrostatic interaction and sterical correspondence between the stationary phase and the various sub-structures of barbituric acid derivatives.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalCroatica Chemica Acta
Issue number1
Publication statusPublished - May 1 2011



  • Barbiturates
  • Porous graphitized carbon
  • Quantitative structure-retention relationship

ASJC Scopus subject areas

  • Chemistry(all)

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