Simultaneous activation of coagulation and fibrinolysis after severe renal ischemia in rats

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Abstract

Coagulation and fibrinolysis were studied during and after bilateral renal artery occlusion for 2 h in rats. After the release of the arterial clamps platelet count and plasma fibrinogen concentration decreased and circulating fibrin monomers were detected. The shortening of euglobulin lysis time and the accumulation of fibrinogen/fibrin degradation products indicated a simultaneous activation of fibrinolysis. Rapid and severe hemolysis was evident by the steadily increasing plasma hemoglobin concentration. Bilateral nephrectomy reversed all these pathological changes.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalNephron
Volume32
Issue number2
Publication statusPublished - Jan 1 1982

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ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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