Simulation of steady-state plasma concentrations using pharmacokinetic parameters calculated from a single-dose experiment: An example with Cordaflex 20-mg retard tablet

I. Klebovich, G. Grezal, K. Balogh Nemes, S. Drabant, V. Horvath, G. Horvai

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Abstract

The pharmacokinetic parameters of repeated-dose treatment with Cordaflex 20-mg nifedipine retard filmtablets were simulated from values calculated on the basis of single-dose study. The results of the simulation were compared with the steady-state parameters determined in a repeated-dose pharmacokinetic study performed in healthy volunteers. The results indicate that the simulation provides good estimates and, accordingly, offers a mathematical method for the planning and evaluation of various pharmacokinetic studies.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalPharmaceutical Sciences
Volume3
Issue number8
Publication statusPublished - Dec 1 1997

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ASJC Scopus subject areas

  • Pharmaceutical Science

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