Simulation of fiber deposition in bronchial airways

I. Balásházy, Mona Moustafa, Werner Hofmann, Réka Szöke, Amer El-Hussein, Abdel Rahman Ahmed

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Penetration probabilities of inhaled man-made mineral fibers to reach central human airways were computed by a stochastic lung deposition model for different flow rates and equivalent diameters. Results indicate that even thick and long fibers can penetrate into the central airways at low flow rates. Deposition efficiencies and localized deposition patterns were then computed for man-made fibers with variable lengths in a three-dimensional physiologically realistic bifurcation model of the central human airways by computational fluid dynamics (CFD) techniques for characteristic breathing patterns. The results obtained for inspiratory flow conditions indicate that deposition efficiencies were highest for parallel orientation of the fibers, increasing with rising flow rate, branching angle, and fiber length at all orientations. Furthermore, deposition patterns were highly inhomogeneous and their localized distributions showed hot spots in the vicinity of the carinal ridge and at the inner sides of the daughter airways. Comparisons with other theoretical results demonstrate that the equivalent diameter concept, if including interception, presents a reasonable approximation for the parameter ranges employed in the present study.

Original languageEnglish
Pages (from-to)717-727
Number of pages11
JournalInhalation Toxicology
Volume17
Issue number13
DOIs
Publication statusPublished - Dec 1 2005

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Mineral Fibers
Fibers
Hydrodynamics
Nuclear Family
Flow rate
Respiration
Lung
Computational fluid dynamics

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Balásházy, I., Moustafa, M., Hofmann, W., Szöke, R., El-Hussein, A., & Ahmed, A. R. (2005). Simulation of fiber deposition in bronchial airways. Inhalation Toxicology, 17(13), 717-727. https://doi.org/10.1080/08958370500224565

Simulation of fiber deposition in bronchial airways. / Balásházy, I.; Moustafa, Mona; Hofmann, Werner; Szöke, Réka; El-Hussein, Amer; Ahmed, Abdel Rahman.

In: Inhalation Toxicology, Vol. 17, No. 13, 01.12.2005, p. 717-727.

Research output: Contribution to journalArticle

Balásházy, I, Moustafa, M, Hofmann, W, Szöke, R, El-Hussein, A & Ahmed, AR 2005, 'Simulation of fiber deposition in bronchial airways', Inhalation Toxicology, vol. 17, no. 13, pp. 717-727. https://doi.org/10.1080/08958370500224565
Balásházy I, Moustafa M, Hofmann W, Szöke R, El-Hussein A, Ahmed AR. Simulation of fiber deposition in bronchial airways. Inhalation Toxicology. 2005 Dec 1;17(13):717-727. https://doi.org/10.1080/08958370500224565
Balásházy, I. ; Moustafa, Mona ; Hofmann, Werner ; Szöke, Réka ; El-Hussein, Amer ; Ahmed, Abdel Rahman. / Simulation of fiber deposition in bronchial airways. In: Inhalation Toxicology. 2005 ; Vol. 17, No. 13. pp. 717-727.
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