Simple, safe, large scale synthesis of 5-arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-aryl-propanoic acids

G. Toth, K. Kövér

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Reaction of aryl aldehydes with Meldrum's acid 2 in the presence of formic acid and triethylamine with 5-arylmethyl Meldrum's acid derivatives 4 at room temperature, whereas at 80-100°C 3-arylpropanoic acids 5 are formed.

Original languageEnglish
Pages (from-to)3067-3074
Number of pages8
JournalSynthetic Communications
Volume25
Issue number19
Publication statusPublished - 1995

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formic acid
Propionates
Aldehydes
Derivatives
Acids
Temperature
Meldrum's acid
triethylamine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Simple, safe, large scale synthesis of 5-arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-aryl-propanoic acids. / Toth, G.; Kövér, K.

In: Synthetic Communications, Vol. 25, No. 19, 1995, p. 3067-3074.

Research output: Contribution to journalArticle

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abstract = "Reaction of aryl aldehydes with Meldrum's acid 2 in the presence of formic acid and triethylamine with 5-arylmethyl Meldrum's acid derivatives 4 at room temperature, whereas at 80-100°C 3-arylpropanoic acids 5 are formed.",
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