Simple approaches to close the open structure of microfluidic chips and connecting them to the macro-world

László Székely, A. Guttman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microchip electrophoresis has a great potential to improve the speed and throughput of chemical and biochemical analyses. Conventional electrophoresis microchip fabrication methods comprise the main steps of channel formation, cover plate binding and access hole construction. While the fabrication of appropriate cover plates and their bonding process are quite essential to the creation of closed microfluidic networks, connection means of microchips to the macro-world is one of the most important parts of microchip fabrication. In this paper the most commonly used approaches are discussed for cover plate connector fabrication in conjunction with high and low temperature glue-less binding processes. The microchannels in the glass substrate were fabricated by sawing and powder blasting under regular laboratory settings, i.e., not necessitating the use of a clean-room environment, making in this way broader availability for electrophoresis microchip technology.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume841
Issue number1-2
DOIs
Publication statusPublished - Sep 1 2006

Fingerprint

Microchip Electrophoresis
Microfluidics
Macros
Electrophoresis
Fabrication
Controlled Environment
Clean rooms
Sawing
Adhesives
Powders
Glass
Glues
Blasting
Microchannels
Technology
Temperature
Throughput
Availability
Substrates

Keywords

  • Connections
  • Cover plate binding
  • General laboratory setting
  • Microfabrication

ASJC Scopus subject areas

  • Biochemistry

Cite this

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