Similarities between hemispheric blood volume and hypothalamic blood flow changes following L-NAME induced NOS blockade in rats

P. Sándor, Sz Murányi, J. Bencze, M. V-Harvich, K. Komjáti

Research output: Contribution to journalArticle

Abstract

The role of the L-arginine-nitric oxide (NO) system in the regulation of the steady state hypothalamic blood flow (HBF) and the hemispheric blood volume (CBV) was investigated simultaneously, in Urethane anesthetized (1.5 g/kg i.p.), ventilated, normotensive rats (n=14). PaO2, PaCO2 and arterial pH were kept in the normal range during the whole study. Steady state HBF was measured with the H2-gas clearance technique and CBV was recorded continuously by Tomta's photoelectric method, in our modification (Sándor et al. Life Sci., 1986). The L-NAME induced NOS blockade resulted in a dose dependent reduction of the hemispheric blood volume as well asof the regional blood flow. The steady state control CBV decreased from 5.25±0.72 vol % to 4.13±0.51 vol % (p

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

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blood volume
NG-Nitroarginine Methyl Ester
Blood Volume
blood flow
Rats
Blood
Urethane
rats
Regional Blood Flow
Arginine
urethane
Nitric Oxide
Reference Values
Gases
nitric oxide
arginine
gases
dosage
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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Similarities between hemispheric blood volume and hypothalamic blood flow changes following L-NAME induced NOS blockade in rats. / Sándor, P.; Murányi, Sz; Bencze, J.; V-Harvich, M.; Komjáti, K.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

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AU - Komjáti, K.

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