Similarities and dissimilarities of newborn and adolescent rats in the binding capacity of thymic glucocorticoid receptors

G. Csaba, Ágnes Inczefi-Gonda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The glucocorticoid receptor of the newborn thymus binds dexamethasone with the same specificity, as the adult ones. The best competitors of dexamethasone on the glucocorticoid receptor are dexamethasone itself and mifepristone (RU486). Estradiol can compete with dexamethasone on the glucocorticoid receptor. This is true in the case of newborn or adolescent thymus alike. Allylestrenol can slightly compete with dexamethasone on the glucocorticoid receptor in newborn, however this does not occur in adolescents. The other ligands - causing imprinting or imprinting like phenomenon earlier - as tocopherol, menadione, retinoic acid, vitamin D3 - do not compete in vitro with dexamethasone on the thymic glucocorticoid receptor in newborn and adolescent animals. Possibilities of imprinting mechanism, considering the results are discussed.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalMechanisms of Ageing and Development
Volume122
Issue number3
DOIs
Publication statusPublished - Apr 30 2001

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Keywords

  • Estrogen receptor
  • Glucocorticoid receptor
  • Hormonal imprinting
  • Hormone receptor
  • Newborn
  • Thymus

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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