Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer

Dávid Kovács, Krisztina Szoke, Nóra Igaz, G. Spengler, J. Molnár, Tímea Tóth, Dániel Madarász, Zsolt Rázga, Z. Kónya, I. Boros, Mónika Kiricsi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The emergence of multidrug resistant (MDR) cancer phenotypes dramatically attenuates the efficiency of antineoplastic drug treatments often leading to the failure of chemotherapy. Therefore there is an urgent need to engineer new therapeutically useful agents and propose innovative approaches able to defeat resistant cancer cells. Although the remarkable anti-cancer features of silver nanoparticles (AgNPs) have already been delineated their impact on MDR cancer has never been investigated. Herein, we report that AgNPs have notable anti-proliferative effect and induce apoptosis mediated cell death both in drug sensitive and in MDR cancer cells. Furthermore we show evidence that AgNPs exert an inhibitory action on the efflux activity of MDR cancer cells which feature could be exploited to enhance drug accumulation. We verified synergistic interactions of AgNPs with six different antineoplastic agents on drug resistant cells which emphasizes the excellent potential of AgNPs as combinational partners in the chemotherapy of MDR cancer.

Original languageEnglish
Pages (from-to)601-610
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - Apr 1 2016

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ATP-Binding Cassette Transporters
Chemotherapy
Silver
Nanoparticles
Cells
Cell death
Drug Therapy
Antineoplastic Agents
Pharmaceutical Preparations
Drug therapy
Neoplasms
Apoptosis
Engineers
Cell Death
Phenotype

Keywords

  • Combinational therapy
  • Multidrug resistance
  • Silver nanoparticles

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer. / Kovács, Dávid; Szoke, Krisztina; Igaz, Nóra; Spengler, G.; Molnár, J.; Tóth, Tímea; Madarász, Dániel; Rázga, Zsolt; Kónya, Z.; Boros, I.; Kiricsi, Mónika.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 12, No. 3, 01.04.2016, p. 601-610.

Research output: Contribution to journalArticle

Kovács, Dávid ; Szoke, Krisztina ; Igaz, Nóra ; Spengler, G. ; Molnár, J. ; Tóth, Tímea ; Madarász, Dániel ; Rázga, Zsolt ; Kónya, Z. ; Boros, I. ; Kiricsi, Mónika. / Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2016 ; Vol. 12, No. 3. pp. 601-610.
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