Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

Ágnes Szegedi, Margarita Popova, Krassimira Yoncheva, Judit Makk, Judith Mihály, Pavletta Shestakova

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Silver sulfadiazine (AgSD) is the leading topical antibacterial agent for the treatment of burn wound infections. Antibacterial effect of AgSD is limited by its poor aqueous solubility, and antibacterial activity develops only by decomposition of AgSD to silver ions and sulfadiazine. In this study, it is for the first time that application of silver-modified nanoporous silica carriers (MCM-41 or SBA-15) loaded with sulfadiazine (SD), instead of silver sulfadiazine, overcoming the abovementioned disadvantages has been demonstrated. By direct or post synthesis methods, 5-15 nm sized silver nanoparticles can be stabilized in the channels or on the outer surface of nanoporous silica supports; moreover, the empty channels can be loaded by SD molecules. The SD-loaded, silver-modified materials show sustained release properties and similar or even better antimicrobial properties than AgSD. Adsorption of AgSD on nanoporous silica particles significantly improves its water solubility.

Original languageEnglish
Pages (from-to)6283-6292
Number of pages10
JournalJournal of Materials Chemistry B
Volume2
Issue number37
DOIs
Publication statusPublished - Oct 7 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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