Silver and quercetin loaded nanostructured silica materials as potential dermal formulations

I. Trendafilova, D. Momekova, A. Szegedi, G. Momekov, D. Zgureva, S. Boycheva, M. Popova

Research output: Contribution to journalArticle

Abstract

In this study it was demonstrated for the first time that the application of silver modified nanoporous silica as a carrier of natural flavonoid quercetin leads to the formation of efficient dermal formulation. By direct or post synthesis methods finely dispersed silver nanoparticles can be stabilized in the channels or on the outer surface of nanoporous silica support. High quercetin loading capacity (over 40 wt. %) could be achieved on the parent and Ag-containing MCM-41 samples. The in vitro release process at pH=5.5 showed slower quercetin release from Ag-modified MCM-41 samples compared to the parent one. The cytotoxic experiments evidenced that quercetin encapsulated in Ag-modified silica carriers has superior antineoplastic potential against HUT-29 cells compared to free drug.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalBulgarian Chemical Communications
Volume49
Publication statusPublished - Jan 1 2017

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Quercetin
Silver
Silicon Dioxide
Flavonoids
Antineoplastic Agents
Nanoparticles
Pharmaceutical Preparations
Experiments
MCM-41

Keywords

  • Nanoporous silica
  • Quercetin
  • Silver
  • Spherical MCM-41

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Trendafilova, I., Momekova, D., Szegedi, A., Momekov, G., Zgureva, D., Boycheva, S., & Popova, M. (2017). Silver and quercetin loaded nanostructured silica materials as potential dermal formulations. Bulgarian Chemical Communications, 49, 51-58.

Silver and quercetin loaded nanostructured silica materials as potential dermal formulations. / Trendafilova, I.; Momekova, D.; Szegedi, A.; Momekov, G.; Zgureva, D.; Boycheva, S.; Popova, M.

In: Bulgarian Chemical Communications, Vol. 49, 01.01.2017, p. 51-58.

Research output: Contribution to journalArticle

Trendafilova, I, Momekova, D, Szegedi, A, Momekov, G, Zgureva, D, Boycheva, S & Popova, M 2017, 'Silver and quercetin loaded nanostructured silica materials as potential dermal formulations', Bulgarian Chemical Communications, vol. 49, pp. 51-58.
Trendafilova I, Momekova D, Szegedi A, Momekov G, Zgureva D, Boycheva S et al. Silver and quercetin loaded nanostructured silica materials as potential dermal formulations. Bulgarian Chemical Communications. 2017 Jan 1;49:51-58.
Trendafilova, I. ; Momekova, D. ; Szegedi, A. ; Momekov, G. ; Zgureva, D. ; Boycheva, S. ; Popova, M. / Silver and quercetin loaded nanostructured silica materials as potential dermal formulations. In: Bulgarian Chemical Communications. 2017 ; Vol. 49. pp. 51-58.
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