Silibinin (Legalon-70®) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum

L. Kalmár, J. Kádár, A. Somogyi, P. Gergely, G. Csomós, J. Fehér

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Experiments reported here were designed to investigate the effect of silibinin (extracted from Silybum marianum) on human polymorphonuclear leukocyte (PMN) motility and on leukocyte immobilizing activity of lymphokine (leukocyte inhibitory factor, LIF), formyl-Met-Leu-Phe (fMLP), calcium ionophore A-23187 and human sera inactivated by heat (HI-S). In the in vitro experiments, silibinin (1-10 μg/ml) failed to influence the random motility of unstimulated PMNS in agarose droplet assay, but enhanced the motility of the PMNs immobilized by fMLP, calcium inophore, LIF or by autologous human sera. In the in vivo study, silibinin (Legalon-70®) two hours after the administration was effective in enhancing spontaneous motility of leukocytes obtained from healthy volunteers which action could be regarded as a consequence of the decrease of leukocyte immobilizing activity being present in normal human plasma.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalAgents and Actions
Volume29
Issue number3-4
DOIs
Publication statusPublished - Mar 1990

Fingerprint

Silymarin
Calcium Ionophores
Lymphokines
Neutrophils
methionyl-leucyl-phenylalanine
Leukocytes
Serum
Plasma (human)
Milk Thistle
Sepharose
Assays
Calcimycin
Experiments
Calcium
Healthy Volunteers
Hot Temperature
silybin
leukocyte inhibitory factor

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Silibinin (Legalon-70®) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum. / Kalmár, L.; Kádár, J.; Somogyi, A.; Gergely, P.; Csomós, G.; Fehér, J.

In: Agents and Actions, Vol. 29, No. 3-4, 03.1990, p. 239-246.

Research output: Contribution to journalArticle

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abstract = "Experiments reported here were designed to investigate the effect of silibinin (extracted from Silybum marianum) on human polymorphonuclear leukocyte (PMN) motility and on leukocyte immobilizing activity of lymphokine (leukocyte inhibitory factor, LIF), formyl-Met-Leu-Phe (fMLP), calcium ionophore A-23187 and human sera inactivated by heat (HI-S). In the in vitro experiments, silibinin (1-10 μg/ml) failed to influence the random motility of unstimulated PMNS in agarose droplet assay, but enhanced the motility of the PMNs immobilized by fMLP, calcium inophore, LIF or by autologous human sera. In the in vivo study, silibinin (Legalon-70{\circledR}) two hours after the administration was effective in enhancing spontaneous motility of leukocytes obtained from healthy volunteers which action could be regarded as a consequence of the decrease of leukocyte immobilizing activity being present in normal human plasma.",
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AU - Kádár, J.

AU - Somogyi, A.

AU - Gergely, P.

AU - Csomós, G.

AU - Fehér, J.

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