Silent Philadelphia chromosome A distinct developmental stage in a Philadelphia chromosome-positive chronic myeloproliferation?

László Pajor, János A. Vass, László Kereskai, Károly Szuhai, Lenke Molnár, Pál Jáksó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this paper, a patient is described who presented with peripheral blood and bone marrow features uncharacteristic of chronic granulocytic leukemia, which proved to be Philadelphia (Ph) chromosome-positive by metaphase and interphase cytogenetic analyses but lacked the p210 type of BCR/ABL fusion gene mRNA product by two different sensitive RT-PCR assays. In the course of the 32-month follow-up with a termination into a myeloblastic crisis, molecular investigations were performed four times. They indicated a constantly high rate of Ph positive cells and lack of BCR/ABL mRNA expression, except in the second investigation, when the patient showed reverse transcription polymerase chain reaction positivity with b3/a2 type of chimera, fusion gene mRNA expression, and a striking change in the bone marrow histology. Our findings might indicate that the dormant Ph chromosome state may exist not only at the primitive progenitor, but also at the entire peripheral blood cell compartment level. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume118
Issue number1
DOIs
Publication statusPublished - Apr 1 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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