Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina

Kim M. Fox, Udho Thadani, Patrick T.S. Ma, Stephen D. Nash, Zoe Keating, Michael A. Czorniak, Hunter Gillies, Mátyás Keltai

Research output: Contribution to journalArticle

75 Citations (Scopus)


Aims: The aim of this study was to evaluate whether sildenafil, used for treatment of erectile dysfunction (ED), affects the exercise tolerance and ischaemic threshold in men with exercise-induced angina not taking nitrates. Methods: This was a double-blind placebo-controlled study in men with ED and chronic stable angina, assessing the effect of sildenafil on time to limiting angina during incremental treadmill exercise. Patients remained on their antianginal therapy and received a 100-mg dose of sildenafil or placebo 1 h prior to treadmill exercise. Other measurements included times to onset of angina, 1-mm ST-segment depression, and total exercise time. Results: Adjusted treatment differences for the time to limiting angina, time to onset of angina, total exercise time, and time to 1-mm ST-segment depression were (mean±SE) 20±10 s (95% CI, 1-39; P=0.040), 32±11 s (95% CI, 11-53; P=0.004), 20±10 s (95% CI, 0-39; P=0.049), and 12±17 s (95% CI, -21 to 45, P=0.48), respectively, in favour of sildenafil There were no serious treatment-related adverse events. Conclusion: Sildenafil was well tolerated and did not adversely affect any exercise parameter in men with coronary artery disease and ED. Favourable trends in total exercise duration and times to onset of angina and limiting angina were recorded with sildenafil use.

Original languageEnglish
Pages (from-to)2206-2212
Number of pages7
JournalEuropean heart journal
Issue number24
Publication statusPublished - Dec 1 2003


  • Angina
  • Erectile dysfunction
  • Exercise tolerance
  • Ischaemia
  • ST-segment depression
  • Sildenafil citrate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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