Significant differences in the interleukin-1β and interleukin-1 receptor antagonist gene polymorphisms in a Hungarian population with inflammatory bowel disease

A. Nemetz, A. Köpe, T. Molnár, Á Kovács, J. Fehér, Z. Tulassay, F. Nagy, M. A. García-González, A. S. Peña

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: There is growing evidence of the importance of genetic predisposition and the activation of the mucosal immune system in the pathogenesis of inflammatory bowel disease. Thus, genes involved in the regulation of inflammation are receiving increased attention. We have Studied whether Crohn's disease (CD) or ulcerative colitis (UC) is associated with certain allelic combinations of ILIB/ILIRA gene polymorphisms in a different European population than the ones studied so far. Methods: Ninety-six patients with UC, 97 with CD, and 132 healthy individuals (HC) were typed for the polymorphic regions in exon 5 of the ILIB gene and in intron 2 of the ILIRA gene, using polymerase chain reaction-based methods. Results: In CD homozygotes for allele 1 in ILIB gene polymorphism were more often present (72% versus 28%; P = 0.01) in the subgroup of patients carrying at least one copy of allele 2 in/LIRA gene polymorphism. This association was not found in HC (HC versus CD; P = 0.03) or UC. However, in UC patients with pancolitis a similar trend was observed (75% versus 25%). Several genotype combinations characterized by the presence of allele 2 of the ILIRA gene polymorphism were more common in CD (P = 0.001) and UC (P = 0.049) than in HC. Conclusions: Our data support the concept that CD and severe UC have a genetic disequilibrium in the distribution of ILIB and ILIRA gene polymorphisms. These findings together with functional studies will contribute to the understanding of the pathogenesis of the chronicity of inflammation in these diseases.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalScandinavian journal of gastroenterology
Volume34
Issue number2
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Crohn's disease
  • Gene polymorphisms
  • Inflammatory bowel disease
  • Interleukin-1̄/interleukin- 1 receptor antagonist
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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