Significance of histochemical demonstration of oxidative enzymes in interpretation of the immediate and remote effects of experimental brain lesions (Hungarian)

D. Bara, Z. Botiz, L. Sztriha, J. Skaliczki

Research output: Contribution to journalArticle

Abstract

In cortex, habenular or hypothalamic regions of white rats, electrocoagulation was carried out. Animals were killed from 6 days to 5 mth after the operation. Serial slides of the brain were investigated by the aid of a reaction of succinate dehydrogenase, glycerophosphate dehydrogenase, lactate dehydrogenase, glucose 6 phosphate dehydrogenase, triphosphopyridine nucleotide diaphorase (SDH, α GPDH, LDH, G6PDH, TPND). Group of neurons around the lesion may show a decreased, normal and increased activity of the enzymes investigated. As for the far effect of the lesion in case of the injury of the postcomissural fornix changes could have to be revealed in the corpus mamillare. Activation of neuroglia is marked by the increase of the reaction of G6PDH, LDH and TPNDH. Enzyme activity of cells of microglial origin at the beginning seems to be significant, later on, when the activity of phagocytes comes to the end it decreases to the minimum. Regeneration of cells of the leptomeninges and their role in demarcation of the process is marked by the increase of enzyme activity.

Original languageEnglish
Pages (from-to)64-72
Number of pages9
JournalMorphologiai es Igazsagugyi Orvosi Szemle
Volume15
Issue number1
Publication statusPublished - Jan 1 1975

ASJC Scopus subject areas

  • Medicine(all)

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