Signet-ring cell carcinoma of the urinary bladder can be primary, arising from the bladder wall or urachus remnants, or secondary to primary tumours originating mostly from the stomach, colon or breast. CASE REPORT - We report the case of a 45-year-old woman who presented with gross haematuria. Cystoscopy revealed a necrotic tumour on the left bladder wall. The histological examination of the sample obtained by transurethral biopsy showed a signet-ring cell carcinoma. The presence of a primary tumour in the gastrointestinal tract was ruled out, which suggested the bladder origin of the tumour. Radical cystectomy was performed with uretero-sigmoido-stomy (Mainz Pouch II). Histology confirmed the diagnosis of primary signet-ring cell carcinoma of the bladder (pT3NOMO). Surgical treatment was followed by adjuvant cisplatin-fluorouracil chemotherapy. CONCLUSIONS - Primary signet-ring carcinoma of urinary bladder is very rare, accounting only for approximately 0.24% of all bladder malignancies. It has a poor prognosis, but our patient is free of disease 5 years after radical cystectomy.
|Number of pages||3|
|Journal||Lege Artis Medicinae|
|Publication status||Published - May 1 2008|
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