Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins

A. Fehér, Dézi Bianka Lajkó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rho-type small GTP-binding plant proteins function as two-state molecular switches in cellular signalling. There is accumulating evidence that Rho-of-plants (ROP) signalling is positively controlled by plant receptor kinases, through the ROP guanine nucleotide exchange factor proteins. These signalling modules regulate cell polarity, cell shape, hormone responses, and pathogen defence, among other things. Other ROP-regulatory proteins might also be subjected to protein phosphorylation by cellular kinases (e.g., mitogen-activated protein kinases or calcium-dependent protein kinases), in order to integrate various cellular signalling pathways with ROP GTPase-dependent processes. In contrast to the role of kinases in upstream ROP regulation, much less is known about the potential link between ROP GTPases and downstream kinase signalling. In other eukaryotes, Rho-type G-protein-activated kinases are widespread and have a key role in many cellular processes. Recent data indicate the existence of structurally different ROP-activated kinases in plants, but their ROP-dependent biological functions still need to be validated. In addition to these direct interactions, ROPs may also indirectly control the activity of mitogen-activated protein kinases or calcium-dependent protein kinases. These kinases may therefore function as upstream as well as downstream kinases in ROP-mediated signalling pathways, such as the phosphatidylinositol monophosphate kinases involved in cell polarity establishment.

Original languageEnglish
Pages (from-to)93-107
Number of pages15
JournalPlant Science
Volume237
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Monomeric GTP-Binding Proteins
G-proteins
phosphotransferases (kinases)
Phosphotransferases
rho GTP-Binding Proteins
cell communication
Cell Polarity
Plant Proteins
guanosinetriphosphatase
plant proteins
Mitogen-Activated Protein Kinases
protein kinases
Rho Guanine Nucleotide Exchange Factors
calcium
mitogen-activated protein kinase kinase
Cell Shape
protein phosphorylation
regulatory proteins
phosphatidylinositols
Phosphatidylinositols

Keywords

  • Guanine nucleotide exchange factor
  • Mitogen-activated protein kinase
  • Protein phosphorylation
  • Receptor-like kinase
  • ROP GTPase
  • ROP-binding kinase

ASJC Scopus subject areas

  • Plant Science
  • Genetics
  • Agronomy and Crop Science

Cite this

Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins. / Fehér, A.; Lajkó, Dézi Bianka.

In: Plant Science, Vol. 237, 01.08.2015, p. 93-107.

Research output: Contribution to journalArticle

Fehér, A. ; Lajkó, Dézi Bianka. / Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins. In: Plant Science. 2015 ; Vol. 237. pp. 93-107.
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