Signalling mechanisms in erythropoiesis

The enigmatic role of calcium

András Schaefer, Mária Magócsi, Hans Marquardt

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The glycoprotein hormone, erythropoietin is the principal regulator of the production of circulating erythrocytes by controlling proliferation differentiation and survival of its target erythroid progenitor cells. The receptor for erythropoietin is a type I cytokine receptor lacking intrinsic tyrosine kinase activity. It mediates tyrosine phosphorylation through its association with nonreceptor tyrosine kinases such as JAK2 and initiates a cascade of signalling events in response to erythropoietin. Significant progress has been made in identifying signalling pathways triggered by erythropoietin. However, the tract signalling mechanisms mediating the known physiological effects of erythropoietin in erythroid progenitor cells are poorly understood. There are many open questions including the role of Ca2+ in erythropoietin induced signal transduction. Although the results concerning the effect of erythropoietin on [Ca2+](i) in various erythroid cells are conflicting, [Ca2+](i)-increasing agents mimic the effect of erythropoietin on c-myb expression and activate the program of haemoglobin synthesis in murine erythroleukemia cells. An attempt is made in this review to survey recent data on the erythropoietin-induced signal transduction with respect to the different physiological effects of this hormone.

Original languageEnglish
Pages (from-to)483-495
Number of pages13
JournalCellular Signalling
Volume9
Issue number7
DOIs
Publication statusPublished - Nov 1997

Fingerprint

Erythropoiesis
Erythropoietin
Calcium
Erythroid Precursor Cells
Protein-Tyrosine Kinases
Signal Transduction
Hormones
Erythropoietin Receptors
Leukemia, Erythroblastic, Acute
Erythroid Cells
Cytokine Receptors
Tyrosine
Glycoproteins
Hemoglobins
Erythrocytes
Phosphorylation

Keywords

  • Apoptosis
  • c-myb
  • Calcium
  • Cell proliferation
  • Differentiation
  • Erythropoietin
  • Signal transduction

ASJC Scopus subject areas

  • Cell Biology

Cite this

Signalling mechanisms in erythropoiesis : The enigmatic role of calcium. / Schaefer, András; Magócsi, Mária; Marquardt, Hans.

In: Cellular Signalling, Vol. 9, No. 7, 11.1997, p. 483-495.

Research output: Contribution to journalArticle

Schaefer, András ; Magócsi, Mária ; Marquardt, Hans. / Signalling mechanisms in erythropoiesis : The enigmatic role of calcium. In: Cellular Signalling. 1997 ; Vol. 9, No. 7. pp. 483-495.
@article{9cd5b43fcd52493a859f3ae43c8e8bb1,
title = "Signalling mechanisms in erythropoiesis: The enigmatic role of calcium",
abstract = "The glycoprotein hormone, erythropoietin is the principal regulator of the production of circulating erythrocytes by controlling proliferation differentiation and survival of its target erythroid progenitor cells. The receptor for erythropoietin is a type I cytokine receptor lacking intrinsic tyrosine kinase activity. It mediates tyrosine phosphorylation through its association with nonreceptor tyrosine kinases such as JAK2 and initiates a cascade of signalling events in response to erythropoietin. Significant progress has been made in identifying signalling pathways triggered by erythropoietin. However, the tract signalling mechanisms mediating the known physiological effects of erythropoietin in erythroid progenitor cells are poorly understood. There are many open questions including the role of Ca2+ in erythropoietin induced signal transduction. Although the results concerning the effect of erythropoietin on [Ca2+](i) in various erythroid cells are conflicting, [Ca2+](i)-increasing agents mimic the effect of erythropoietin on c-myb expression and activate the program of haemoglobin synthesis in murine erythroleukemia cells. An attempt is made in this review to survey recent data on the erythropoietin-induced signal transduction with respect to the different physiological effects of this hormone.",
keywords = "Apoptosis, c-myb, Calcium, Cell proliferation, Differentiation, Erythropoietin, Signal transduction",
author = "Andr{\'a}s Schaefer and M{\'a}ria Mag{\'o}csi and Hans Marquardt",
year = "1997",
month = "11",
doi = "10.1016/S0898-6568(97)00094-6",
language = "English",
volume = "9",
pages = "483--495",
journal = "Cellular Signalling",
issn = "0898-6568",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Signalling mechanisms in erythropoiesis

T2 - The enigmatic role of calcium

AU - Schaefer, András

AU - Magócsi, Mária

AU - Marquardt, Hans

PY - 1997/11

Y1 - 1997/11

N2 - The glycoprotein hormone, erythropoietin is the principal regulator of the production of circulating erythrocytes by controlling proliferation differentiation and survival of its target erythroid progenitor cells. The receptor for erythropoietin is a type I cytokine receptor lacking intrinsic tyrosine kinase activity. It mediates tyrosine phosphorylation through its association with nonreceptor tyrosine kinases such as JAK2 and initiates a cascade of signalling events in response to erythropoietin. Significant progress has been made in identifying signalling pathways triggered by erythropoietin. However, the tract signalling mechanisms mediating the known physiological effects of erythropoietin in erythroid progenitor cells are poorly understood. There are many open questions including the role of Ca2+ in erythropoietin induced signal transduction. Although the results concerning the effect of erythropoietin on [Ca2+](i) in various erythroid cells are conflicting, [Ca2+](i)-increasing agents mimic the effect of erythropoietin on c-myb expression and activate the program of haemoglobin synthesis in murine erythroleukemia cells. An attempt is made in this review to survey recent data on the erythropoietin-induced signal transduction with respect to the different physiological effects of this hormone.

AB - The glycoprotein hormone, erythropoietin is the principal regulator of the production of circulating erythrocytes by controlling proliferation differentiation and survival of its target erythroid progenitor cells. The receptor for erythropoietin is a type I cytokine receptor lacking intrinsic tyrosine kinase activity. It mediates tyrosine phosphorylation through its association with nonreceptor tyrosine kinases such as JAK2 and initiates a cascade of signalling events in response to erythropoietin. Significant progress has been made in identifying signalling pathways triggered by erythropoietin. However, the tract signalling mechanisms mediating the known physiological effects of erythropoietin in erythroid progenitor cells are poorly understood. There are many open questions including the role of Ca2+ in erythropoietin induced signal transduction. Although the results concerning the effect of erythropoietin on [Ca2+](i) in various erythroid cells are conflicting, [Ca2+](i)-increasing agents mimic the effect of erythropoietin on c-myb expression and activate the program of haemoglobin synthesis in murine erythroleukemia cells. An attempt is made in this review to survey recent data on the erythropoietin-induced signal transduction with respect to the different physiological effects of this hormone.

KW - Apoptosis

KW - c-myb

KW - Calcium

KW - Cell proliferation

KW - Differentiation

KW - Erythropoietin

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=0343196697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343196697&partnerID=8YFLogxK

U2 - 10.1016/S0898-6568(97)00094-6

DO - 10.1016/S0898-6568(97)00094-6

M3 - Article

VL - 9

SP - 483

EP - 495

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 7

ER -