Signal transduction in human myometrial cells

M. Molnár, J. Rigó, F. Hertelendy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calcium plays a pivotal role in the contraction-relaxation cycle of uterine smooth muscle. We investigated the effects of three uterine agonists; prostaglandin F (PGF), oxytocin and platelet activating factor (PAF) on intracellular levels of Ca ([Ca2+]i) in intact human myometrial cells and 45Ca2+ efflux from permeabilized myocytes. We observed that, whereas oxytocin and PAF activated the phosphoinositide cycle, generating inositol triphosphate to mobilize intracellular Ca2+, PGF acted mainly to enhance Ca2+ influx. Oxytocin-, but not PGF-elicited responses were suppressed by pertussis toxin. It is concluded that all three agonists act by regulating [Ca2+]i in myometrial cells, but the signal transduction mechanism of PGF differs from that of oxytocin and PAF.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalActa physiologica Hungarica
Volume84
Issue number2
Publication statusPublished - Dec 1 1996

Keywords

  • Calcium mobilization
  • Human myometrium
  • Platelet activating factor
  • Prostaglandin F
  • Signal transduction

ASJC Scopus subject areas

  • Physiology (medical)

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  • Cite this

    Molnár, M., Rigó, J., & Hertelendy, F. (1996). Signal transduction in human myometrial cells. Acta physiologica Hungarica, 84(2), 89-97.