Signal transduction in human myometrial cells

M. Molnár, J. Rigó, F. Hertelendy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calcium plays a pivotal role in the contraction-relaxation cycle of uterine smooth muscle. We investigated the effects of three uterine agonists; prostaglandin F (PGF), oxytocin and platelet activating factor (PAF) on intracellular levels of Ca ([Ca2+]i) in intact human myometrial cells and 45Ca2+ efflux from permeabilized myocytes. We observed that, whereas oxytocin and PAF activated the phosphoinositide cycle, generating inositol triphosphate to mobilize intracellular Ca2+, PGF acted mainly to enhance Ca2+ influx. Oxytocin-, but not PGF-elicited responses were suppressed by pertussis toxin. It is concluded that all three agonists act by regulating [Ca2+]i in myometrial cells, but the signal transduction mechanism of PGF differs from that of oxytocin and PAF.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalActa Physiologica Hungarica
Volume84
Issue number2
Publication statusPublished - 1996

Fingerprint

Dinoprost
Oxytocin
Platelet Activating Factor
Signal Transduction
Myometrium
Pertussis Toxin
Inositol
Phosphatidylinositols
Muscle Cells
Smooth Muscle
Calcium

Keywords

  • Calcium mobilization
  • Human myometrium
  • Platelet activating factor
  • Prostaglandin F
  • Signal transduction

ASJC Scopus subject areas

  • Physiology

Cite this

Molnár, M., Rigó, J., & Hertelendy, F. (1996). Signal transduction in human myometrial cells. Acta Physiologica Hungarica, 84(2), 89-97.

Signal transduction in human myometrial cells. / Molnár, M.; Rigó, J.; Hertelendy, F.

In: Acta Physiologica Hungarica, Vol. 84, No. 2, 1996, p. 89-97.

Research output: Contribution to journalArticle

Molnár, M, Rigó, J & Hertelendy, F 1996, 'Signal transduction in human myometrial cells', Acta Physiologica Hungarica, vol. 84, no. 2, pp. 89-97.
Molnár, M. ; Rigó, J. ; Hertelendy, F. / Signal transduction in human myometrial cells. In: Acta Physiologica Hungarica. 1996 ; Vol. 84, No. 2. pp. 89-97.
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