Signal convergence on protein kinase A as a molecular correlate of learning

András Aszódi, Uli Müller, Peter Friedrich, Hanns Christof Spatz

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The response of a reaction network composed of protein kinase A, calpain, and protein phosphatase to transient cAMP and Ca2+ signals was studied. An essential feature of signal convergence is that the regulatory subunit of cAMP-dissociated protein kinase A undergoes limited proteolysis by the Ca2+-activated proteinase calpain. A dynamic model of this system based on kinetic differential equations was built and simulated by computer. The system shows analogies to typical features of associative learning such as acquisition, contiguity detection, extinction, and memory decay, suggesting that these biochemical reactions may be part of the molecular mechanism of learning in Drosophila.

Original languageEnglish
Pages (from-to)5832-5836
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number13
DOIs
Publication statusPublished - Jul 1 1991

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Keywords

  • Acquisition
  • Ca-dependent proteolytic
  • Contiguity
  • Memory
  • Modification
  • Phosphorylation

ASJC Scopus subject areas

  • General

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