Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [11C]SA4503

Nisha K. Ramakrishnan, Anniek K D Visser, Anna A. Rybczynska, C. Nyakas, Paul G M Luiten, Chantal Kwizera, Jurgen W A Sijbesma, Philip H. Elsinga, Kiichi Ishiwata, Rudi A J O Dierckx, Aren van Waarde

Research output: Contribution to journalArticle

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Abstract

Purpose: Sigma-1 receptor ligands modulate the release of several neurotransmitters and intracellular calcium signaling. We examined the binding of a radiolabeled sigma-1 agonist in the aging rat brain with positron emission tomography (PET). Procedures: Time-dependent uptake of [11C]SA4503 was measured in the brain of young (1.5 to 3 months) and aged (18 to 32 months) Wistar Hannover rats, and tracer-kinetic models were fitted to this data, using metabolite-corrected plasma radioactivity as input function. Results: In aged animals, the injected probe was less rapidly metabolized and cleared. Logan graphical analysis and a 2-tissue compartment model (2-TCM) fit indicated changes of total distribution volume (VT) and binding potential (BPND) of the tracer. BPND was reduced particularly in the (hypo)thalamus, pons, and medulla. Conclusions: Some areas showed reductions of ligand binding with aging whereas binding in other areas (cortex) was not significantly affected.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalMolecular Imaging and Biology
DOIs
Publication statusAccepted/In press - Dec 4 2015

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Ligands
Calcium Signaling
Pons
Brain
Thalamus
Positron-Emission Tomography
Radioactivity
Neurotransmitter Agents
Wistar Rats
SA 4503
sigma-1 receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Ramakrishnan, N. K., Visser, A. K. D., Rybczynska, A. A., Nyakas, C., Luiten, P. G. M., Kwizera, C., ... van Waarde, A. (Accepted/In press). Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [11C]SA4503. Molecular Imaging and Biology, 1-10. https://doi.org/10.1007/s11307-015-0917-6

Sigma-1 Agonist Binding in the Aging Rat Brain : a MicroPET Study with [11C]SA4503. / Ramakrishnan, Nisha K.; Visser, Anniek K D; Rybczynska, Anna A.; Nyakas, C.; Luiten, Paul G M; Kwizera, Chantal; Sijbesma, Jurgen W A; Elsinga, Philip H.; Ishiwata, Kiichi; Dierckx, Rudi A J O; van Waarde, Aren.

In: Molecular Imaging and Biology, 04.12.2015, p. 1-10.

Research output: Contribution to journalArticle

Ramakrishnan, NK, Visser, AKD, Rybczynska, AA, Nyakas, C, Luiten, PGM, Kwizera, C, Sijbesma, JWA, Elsinga, PH, Ishiwata, K, Dierckx, RAJO & van Waarde, A 2015, 'Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [11C]SA4503', Molecular Imaging and Biology, pp. 1-10. https://doi.org/10.1007/s11307-015-0917-6
Ramakrishnan, Nisha K. ; Visser, Anniek K D ; Rybczynska, Anna A. ; Nyakas, C. ; Luiten, Paul G M ; Kwizera, Chantal ; Sijbesma, Jurgen W A ; Elsinga, Philip H. ; Ishiwata, Kiichi ; Dierckx, Rudi A J O ; van Waarde, Aren. / Sigma-1 Agonist Binding in the Aging Rat Brain : a MicroPET Study with [11C]SA4503. In: Molecular Imaging and Biology. 2015 ; pp. 1-10.
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