Siderophore analogues: A new macrocyclic tetraamine tris(hydroxamate) ligand; synthesis and solution chemistry of the iron(III), aluminium(III) and copper(II) complexes

Margarida Gaspar, Raquel Grazina, A. Bodor, E. Farkas, M. Amélia Santos

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37 Citations (Scopus)

Abstract

A new siderophore analogue TETMAHA (1,4,8,11-tetraazacyclotetradecane-N,N′,N″-tris(N- methylacetohydroxamic acid), a ligand with three hydroxamic acid groups bonded to the macrocycle CYCLAM, has been synthesized and characterized. Its acid-base and chelating properties towards iron(III), aluminium(III) and copper(II) have been studied by potentiometric and spectroscopic techniques. This ligand forms quite stable complexes with those metal ions and the formation constants have been determined. The mechanism of the electron transfer of the iron complexes, thought to be important in the biological activity shown by this ligand, has also been studied by cyclic voltammetry.

Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalJournal of the Chemical Society, Dalton Transactions
Issue number5
Publication statusPublished - Mar 7 1999

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Siderophores
Aluminum
Copper
Iron
Ligands
Hydroxamic Acids
Acids
Chelation
Bioactivity
Cyclic voltammetry
Metal ions
Electrons
cyclam

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

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abstract = "A new siderophore analogue TETMAHA (1,4,8,11-tetraazacyclotetradecane-N,N′,N″-tris(N- methylacetohydroxamic acid), a ligand with three hydroxamic acid groups bonded to the macrocycle CYCLAM, has been synthesized and characterized. Its acid-base and chelating properties towards iron(III), aluminium(III) and copper(II) have been studied by potentiometric and spectroscopic techniques. This ligand forms quite stable complexes with those metal ions and the formation constants have been determined. The mechanism of the electron transfer of the iron complexes, thought to be important in the biological activity shown by this ligand, has also been studied by cyclic voltammetry.",
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T2 - A new macrocyclic tetraamine tris(hydroxamate) ligand; synthesis and solution chemistry of the iron(III), aluminium(III) and copper(II) complexes

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AU - Grazina, Raquel

AU - Bodor, A.

AU - Farkas, E.

AU - Santos, M. Amélia

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