Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

I. Takacs, D. L. Koller, M. Peacock, J. C. Christian, W. E. Evans, S. L. Hui, P. M. Conneally, C. C. Johnston, T. Foroud, M. J. Econs

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31 Citations (Scopus)

Abstract

A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalBone
Volume27
Issue number1
DOIs
Publication statusPublished - Jul 1 2000

Keywords

  • Bone mineral density
  • Interleukin 6
  • Nonparametric linkage

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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    Takacs, I., Koller, D. L., Peacock, M., Christian, J. C., Evans, W. E., Hui, S. L., Conneally, P. M., Johnston, C. C., Foroud, T., & Econs, M. J. (2000). Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus. Bone, 27(1), 169-173. https://doi.org/10.1016/S8756-3282(00)00296-9