Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias

Csaba A. Dézsi, Andrea Szucs, Gábor Szucs, Attila Róka, Orsolya Kiss, David Becker, B. Merkely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Radiofrequency catheter ablation or modification of the atrioventricular junction is an effective therapy of drug refractory supraventricular tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during nonsustained STs. We aimed to examine the effect of sustained STs and the applied rate-control therapy on plasma ET levels. Twenty-two patients (12 men; mean age, 64.4 ± 13.2 years; ejection fraction, 41.8 ± 11.2%; New York Heart Association (NYHA) class I: 3 cases, NYHA II: 11 cases, and NYHA III: 8 cases) suffering of atrial fibrillation (n = 11), atrial flutter (n = 7), atrial paroxysmal tachycardia (n = 3), or sinus tachycardia (n = 1) were studied, having coronary artery disease (n = 8), dilative cardiomyopathy (n = 5), or no underlying diseases (n = 9). All groups went under catheter ablation (same protocol, duration: 35 ± 10.3 mins; rate before ablation, 100-170 /min in every case; after ablation, 70-80 /min in Groups I and II and 70-90 /min in Group III). A pacemaker (PM) was implanted 2 months before ablation in Group I (n = 9) and during ablation in Group II (n = 7). No PM was implanted in Group III (n = 6). A control group (n = 13; 7 men; mean age, 66.15 ± 6.7 years) with sinus rhythm got a PM without ST and ablation. Blood samples were collected from the cubital vein immediately before (control), and 5 mins and 24 hrs after ablation. Plasma ET-1 and big ET-1 levels were measured after immunoprecipitation with Western blot analysis. There were no differences between plasma ET-1 levels in the ST groups and the control group (Groups I, II, and III vs. control group: 0.66 6 0.04 fmol/ml, 0.93 ± 0.12 fmol/ml, and 0.68 ± 0.05 fmol/ml vs. 0.50 ± 0.05 fmol/ml, respectively; P <0.05). Comparing the control, 5-min, and 24-hr samples, ET-1 levels decreased significantly after supraventricular tachycardia ablation in Groups I and III (control vs. Group I, 5 mins and 24 hrs: 0.66 ± 0.04 fmol/ml vs. 0.50 ± 0.04 fmol/ml and 0.29 ± 0.05 fmol/ml; control vs. Group III, 24 hrs: 0.68 ± 0.05 vs. 0.34 ± 0.05 fmol/ml; P <0.05). No plasma big ET-1 changes were measured in any of the groups. The rapid decrease of ET levels after catheter ablation suggests that a high ventricular rate can be a trigger of ET production. PM implantation procedure seems to interfere with the ET decrease in ST patients.

Original languageEnglish
Pages (from-to)852-856
Number of pages5
JournalExperimental Biology and Medicine
Volume231
Issue number6
Publication statusPublished - Jun 2006

Fingerprint

Endothelins
Endothelin-1
Ablation
Tachycardia
Catheter Ablation
Plasmas
Pacemakers
Control Groups
Catheters
Sinus Tachycardia
Paroxysmal Tachycardia
Atrial Flutter
Supraventricular Tachycardia
Cardiomyopathies
Immunoprecipitation
Atrial Fibrillation
Coronary Artery Disease
Veins
Western Blotting
Drug Therapy

Keywords

  • Endothelin
  • Rate control
  • Supraventricular arrhythmia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dézsi, C. A., Szucs, A., Szucs, G., Róka, A., Kiss, O., Becker, D., & Merkely, B. (2006). Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias. Experimental Biology and Medicine, 231(6), 852-856.

Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias. / Dézsi, Csaba A.; Szucs, Andrea; Szucs, Gábor; Róka, Attila; Kiss, Orsolya; Becker, David; Merkely, B.

In: Experimental Biology and Medicine, Vol. 231, No. 6, 06.2006, p. 852-856.

Research output: Contribution to journalArticle

Dézsi, CA, Szucs, A, Szucs, G, Róka, A, Kiss, O, Becker, D & Merkely, B 2006, 'Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias', Experimental Biology and Medicine, vol. 231, no. 6, pp. 852-856.
Dézsi CA, Szucs A, Szucs G, Róka A, Kiss O, Becker D et al. Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias. Experimental Biology and Medicine. 2006 Jun;231(6):852-856.
Dézsi, Csaba A. ; Szucs, Andrea ; Szucs, Gábor ; Róka, Attila ; Kiss, Orsolya ; Becker, David ; Merkely, B. / Short-term effect of rate control on plasma endothelin levels of patients with tachyarrhythmias. In: Experimental Biology and Medicine. 2006 ; Vol. 231, No. 6. pp. 852-856.
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AU - Dézsi, Csaba A.

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AU - Kiss, Orsolya

AU - Becker, David

AU - Merkely, B.

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N2 - Radiofrequency catheter ablation or modification of the atrioventricular junction is an effective therapy of drug refractory supraventricular tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during nonsustained STs. We aimed to examine the effect of sustained STs and the applied rate-control therapy on plasma ET levels. Twenty-two patients (12 men; mean age, 64.4 ± 13.2 years; ejection fraction, 41.8 ± 11.2%; New York Heart Association (NYHA) class I: 3 cases, NYHA II: 11 cases, and NYHA III: 8 cases) suffering of atrial fibrillation (n = 11), atrial flutter (n = 7), atrial paroxysmal tachycardia (n = 3), or sinus tachycardia (n = 1) were studied, having coronary artery disease (n = 8), dilative cardiomyopathy (n = 5), or no underlying diseases (n = 9). All groups went under catheter ablation (same protocol, duration: 35 ± 10.3 mins; rate before ablation, 100-170 /min in every case; after ablation, 70-80 /min in Groups I and II and 70-90 /min in Group III). A pacemaker (PM) was implanted 2 months before ablation in Group I (n = 9) and during ablation in Group II (n = 7). No PM was implanted in Group III (n = 6). A control group (n = 13; 7 men; mean age, 66.15 ± 6.7 years) with sinus rhythm got a PM without ST and ablation. Blood samples were collected from the cubital vein immediately before (control), and 5 mins and 24 hrs after ablation. Plasma ET-1 and big ET-1 levels were measured after immunoprecipitation with Western blot analysis. There were no differences between plasma ET-1 levels in the ST groups and the control group (Groups I, II, and III vs. control group: 0.66 6 0.04 fmol/ml, 0.93 ± 0.12 fmol/ml, and 0.68 ± 0.05 fmol/ml vs. 0.50 ± 0.05 fmol/ml, respectively; P <0.05). Comparing the control, 5-min, and 24-hr samples, ET-1 levels decreased significantly after supraventricular tachycardia ablation in Groups I and III (control vs. Group I, 5 mins and 24 hrs: 0.66 ± 0.04 fmol/ml vs. 0.50 ± 0.04 fmol/ml and 0.29 ± 0.05 fmol/ml; control vs. Group III, 24 hrs: 0.68 ± 0.05 vs. 0.34 ± 0.05 fmol/ml; P <0.05). No plasma big ET-1 changes were measured in any of the groups. The rapid decrease of ET levels after catheter ablation suggests that a high ventricular rate can be a trigger of ET production. PM implantation procedure seems to interfere with the ET decrease in ST patients.

AB - Radiofrequency catheter ablation or modification of the atrioventricular junction is an effective therapy of drug refractory supraventricular tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during nonsustained STs. We aimed to examine the effect of sustained STs and the applied rate-control therapy on plasma ET levels. Twenty-two patients (12 men; mean age, 64.4 ± 13.2 years; ejection fraction, 41.8 ± 11.2%; New York Heart Association (NYHA) class I: 3 cases, NYHA II: 11 cases, and NYHA III: 8 cases) suffering of atrial fibrillation (n = 11), atrial flutter (n = 7), atrial paroxysmal tachycardia (n = 3), or sinus tachycardia (n = 1) were studied, having coronary artery disease (n = 8), dilative cardiomyopathy (n = 5), or no underlying diseases (n = 9). All groups went under catheter ablation (same protocol, duration: 35 ± 10.3 mins; rate before ablation, 100-170 /min in every case; after ablation, 70-80 /min in Groups I and II and 70-90 /min in Group III). A pacemaker (PM) was implanted 2 months before ablation in Group I (n = 9) and during ablation in Group II (n = 7). No PM was implanted in Group III (n = 6). A control group (n = 13; 7 men; mean age, 66.15 ± 6.7 years) with sinus rhythm got a PM without ST and ablation. Blood samples were collected from the cubital vein immediately before (control), and 5 mins and 24 hrs after ablation. Plasma ET-1 and big ET-1 levels were measured after immunoprecipitation with Western blot analysis. There were no differences between plasma ET-1 levels in the ST groups and the control group (Groups I, II, and III vs. control group: 0.66 6 0.04 fmol/ml, 0.93 ± 0.12 fmol/ml, and 0.68 ± 0.05 fmol/ml vs. 0.50 ± 0.05 fmol/ml, respectively; P <0.05). Comparing the control, 5-min, and 24-hr samples, ET-1 levels decreased significantly after supraventricular tachycardia ablation in Groups I and III (control vs. Group I, 5 mins and 24 hrs: 0.66 ± 0.04 fmol/ml vs. 0.50 ± 0.04 fmol/ml and 0.29 ± 0.05 fmol/ml; control vs. Group III, 24 hrs: 0.68 ± 0.05 vs. 0.34 ± 0.05 fmol/ml; P <0.05). No plasma big ET-1 changes were measured in any of the groups. The rapid decrease of ET levels after catheter ablation suggests that a high ventricular rate can be a trigger of ET production. PM implantation procedure seems to interfere with the ET decrease in ST patients.

KW - Endothelin

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