Sex-specific regulation of aging in Caenorhabditis elegans

Bernadette Hotzi, Mónika Kosztelnik, Balázs Hargitai, K. Takács-Vellai, János Barna, Kincso a. Bördén, A. Málnási-Csizmadia, Mónika Lippai, Csaba Ortutay, Caroline Bacquet, Angela Pasparaki, T. Arányi, Nektarios Tavernarakis, T. Vellai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A fascinating aspect of sexual dimorphism in various animal species is that the two sexes differ substantially in lifespan. In humans, for example, women's life expectancy exceeds that of men by 3-7 years. Whether this trait can be attributed to dissimilar lifestyles or genetic (regulatory) factors remains to be elucidated. Herein, we demonstrate that in the nematode Caenorhabditis elegans, the significantly longer lifespan of hermaphrodites-which are essentially females capable of sperm production-over males is established by TRA-1, the terminal effector of the sex-determination pathway. This transcription factor directly controls the expression of daf-16/FOXO, which functions as a major target of insulin/IGF-1 signaling (IIS) and key modulator of aging across diverse animal phyla. TRA-1 extends hermaphrodite lifespan through promoting daf-16 activity. Furthermore, TRA-1 also influences reproductive growth in a DAF-16-dependent manner. Thus, the sex-determination machinery is an important regulator of IIS in this organism. These findings provide a mechanistic insight into how longevity and development are specified unequally in the two genders. As TRA-1 is orthologous to mammalian GLI (glioma-associated) proteins, a similar sex-specific mechanism may also operate in humans to determine lifespan.

Original languageEnglish
JournalAging Cell
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Caenorhabditis elegans
Insulin-Like Growth Factor I
Insulin
Life Expectancy
Glioma
Sex Characteristics
Spermatozoa
Life Style
Transcription Factors
Growth
Proteins

Keywords

  • Aging
  • Caenorhabditis elegans
  • daf-16/FOXO
  • Dauer development
  • Insulin/IGF-1 signaling
  • Sex determination
  • TRA-1/GLI

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

Cite this

Hotzi, B., Kosztelnik, M., Hargitai, B., Takács-Vellai, K., Barna, J., Bördén, K. A., ... Vellai, T. (Accepted/In press). Sex-specific regulation of aging in Caenorhabditis elegans. Aging Cell. https://doi.org/10.1111/acel.12724

Sex-specific regulation of aging in Caenorhabditis elegans. / Hotzi, Bernadette; Kosztelnik, Mónika; Hargitai, Balázs; Takács-Vellai, K.; Barna, János; Bördén, Kincso a.; Málnási-Csizmadia, A.; Lippai, Mónika; Ortutay, Csaba; Bacquet, Caroline; Pasparaki, Angela; Arányi, T.; Tavernarakis, Nektarios; Vellai, T.

In: Aging Cell, 01.01.2018.

Research output: Contribution to journalArticle

Hotzi, B, Kosztelnik, M, Hargitai, B, Takács-Vellai, K, Barna, J, Bördén, KA, Málnási-Csizmadia, A, Lippai, M, Ortutay, C, Bacquet, C, Pasparaki, A, Arányi, T, Tavernarakis, N & Vellai, T 2018, 'Sex-specific regulation of aging in Caenorhabditis elegans', Aging Cell. https://doi.org/10.1111/acel.12724
Hotzi, Bernadette ; Kosztelnik, Mónika ; Hargitai, Balázs ; Takács-Vellai, K. ; Barna, János ; Bördén, Kincso a. ; Málnási-Csizmadia, A. ; Lippai, Mónika ; Ortutay, Csaba ; Bacquet, Caroline ; Pasparaki, Angela ; Arányi, T. ; Tavernarakis, Nektarios ; Vellai, T. / Sex-specific regulation of aging in Caenorhabditis elegans. In: Aging Cell. 2018.
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