Sex ratio of congenital abnormalities in the function of maternal age

A population-based study

Gyula Csermely, R. Urbán, E. Czeizel, Béla Veszprémi

Research output: Contribution to journalArticle

Abstract

Maternal age effect is well-known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities (CAs). The sex ratio (SR), i.e. number of males divided by the number of males and females together, of most CAs deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CAs in a population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. First, SR of 24 CA entities/groups was estimated in 21494 patients with isolated CA. In the next step SR of different maternal age groups was compared to the mean SR of the given CA-groups. The SR of four CA-groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalCongenital Anomalies
Volume55
Issue number2
DOIs
Publication statusPublished - May 1 2015

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Sex Ratio
Maternal Age
Population
Age Groups
Anencephaly
Chromosome Aberrations
Mothers
Newborn Infant

Keywords

  • Anencephaly
  • Congenital abnormalities
  • Craniosynostosis
  • Maternal age
  • Sex ratio

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Sex ratio of congenital abnormalities in the function of maternal age : A population-based study. / Csermely, Gyula; Urbán, R.; Czeizel, E.; Veszprémi, Béla.

In: Congenital Anomalies, Vol. 55, No. 2, 01.05.2015, p. 85-91.

Research output: Contribution to journalArticle

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