Sex hormones in hereditary angioneurotic oedema

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Abstract

OBJECTIVE: The fluctuations in sex hormone levels at the beginning of adolescence, in the perimenopausal period, during pregnancy or during the use of oral contraceptives can precipitate oedematous attacks in hereditary angioneurotic oedema (HANO). Attacks usually disappear after the onset of menopause. This study was undertaken to establish any relationship between the serum levels of sex hormones and the incidence of HANO attacks. PATIENTS AND MEASUREMENTS: Serum levels of LH, FSH, progesterone, oestradiol, testosterone, PRL and SHBG were measured in 78 patients [mean age 30.3 years (range 4-70 years)] with HANO. A questionnaire was used to explore the medical history of adult patients to characterize the evolution and the characteristics of attacks. RESULTS: The number of attacks was significantly higher [odds ratio (OR) 6.36 (1.31-30.81); P = 0.022] in females with high progesterone levels (≥ 4 nmol/l), irrespective of age, menstrual cycle and danazol dose. The OR was even higher [13.4 (2.2-81.4); P = 0.005] when only subcutaneous attacks were considered. Multiple logistic regression analysis demonstrated a significantly lower attack frequency during 1-year follow-up in patients with a higher (40 nmol/l) SHBG level (OR 0.25 (0.07-0.90); P = 0.034). This difference existed independently of age and danazol dose. CONCLUSION: In view of these results, the monitoring of progesterone and SHBG levels can prove useful in the prediction of attacks in hereditary angioneurotic oedema.

Original languageEnglish
Pages (from-to)508-515
Number of pages8
JournalClinical Endocrinology
Volume60
Issue number4
DOIs
Publication statusPublished - Apr 2004

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Hereditary Angioedemas
Gonadal Steroid Hormones
Danazol
Progesterone
Odds Ratio
Menstrual Cycle
Oral Contraceptives
Menopause
Serum
Testosterone
Estradiol
Logistic Models
History
Regression Analysis
Pregnancy
Incidence

ASJC Scopus subject areas

  • Endocrinology

Cite this

Sex hormones in hereditary angioneurotic oedema. / Visy, B.; Füst, G.; Varga, L.; Szendei, G.; Takács, E.; Karádi, I.; Fekete, B.; Harmat, G.; Farkas, H.

In: Clinical Endocrinology, Vol. 60, No. 4, 04.2004, p. 508-515.

Research output: Contribution to journalArticle

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AU - Karádi, I.

AU - Fekete, B.

AU - Harmat, G.

AU - Farkas, H.

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