Sex differences in the biomechanics and contractility of intramural coronary arteries in angiotensin ii-induced hypertension

Máté Mátrai, Judit Hetthéssy, G. Nádasy, E. Monos, B. Székács, S. Várbíró

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: It is well known that sex differences occur in both the pathogenesis and therapy of hypertension. A deeper understanding of the underlying processes may be helpful when planning a personalized therapeutic strategy. Objective: In laboratory animal experiments, we studied the early mechanisms of vascular adaptation of the intramural small coronary arteries that play a fundamental role in the blood supply of the heart. Methods: In our study, an osmotic minipump was implanted into 10 male and 10 female Sprague-Dawley rats. The pump remained in situ for 4 weeks, infusing a dose of 100 ng/kg/min angiotensin II acetate. Four weeks later, the animals were killed, and the intramural coronary arteries from the left coronary branch, which are fundamentally responsible for the blood supply of the heart, were prepared. The pharmacologic reactivity and biomechanical properties of the prepared segments were studied in a tissue bath. Results: The relative heart mass and vessel wall thickness were greater in females than males (0.387 [0.009] g/100 g vs 0.306 [0.006] g/100 g body weight; 41.9 [4.09] μm vs 33.45 [3.37] μm on 50 mm Hg). The vessel tone and vasoconstriction in response to thromboxane agonists were, however, significantly more pronounced in males. The extent of relaxation in response to bradykinin was also greater in females. Although we observed inward eutrophic remodeling in females, an increase in wall stress and elastic modulus dominated in males. Conclusion: The early steps of angiotensin II-dependent hypertension evoked very different adaptation mechanisms in males and females.

Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalGender Medicine
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Angiotensins
hypertension
Biomechanical Phenomena
Sex Characteristics
Coronary Vessels
animal
Hypertension
body weight
Angiotensin II
planning
experiment
Elastic Modulus
Thromboxanes
Laboratory Animals
Bradykinin
Vasoconstriction
Baths
Blood Vessels
Sprague Dawley Rats
Acetates

Keywords

  • coronary arteries
  • estrogen
  • gender difference
  • hypertension
  • testosterone

ASJC Scopus subject areas

  • Medicine(all)
  • Gender Studies

Cite this

Sex differences in the biomechanics and contractility of intramural coronary arteries in angiotensin ii-induced hypertension. / Mátrai, Máté; Hetthéssy, Judit; Nádasy, G.; Monos, E.; Székács, B.; Várbíró, S.

In: Gender Medicine, Vol. 9, No. 6, 12.2012, p. 548-556.

Research output: Contribution to journalArticle

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