Sex differences in prostaglandin metabolism

Á Gecse, Anna Ottlecz, Ilona Schäffer, Anna Bujdosć, G. Telegdy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Prostaglandin E2 (PGE2), PGF2alfa and PGD2 were synthetized from [1-14C]-arachidonic acid by rat kidney medulla microsomal fraction. The formation of each prostaglandin was significantly less in female animals than in males. The rate of inactivation of [3H]-PGF2alfa by kidney cortex cytosol was almost linear with the time of incubation during the first 30 min. The production of PGF2alfa metabolite (13,14-dihydro-15-keto PGF2alfa) was higher in male rats than in females.

Original languageEnglish
Pages (from-to)643-647
Number of pages5
JournalBiochemical and biophysical research communications
Volume86
Issue number3
DOIs
Publication statusPublished - Feb 14 1979

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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