Sex differences in oestrogen-induced p44/42 MAPK phosphorylation in mouse brain in vivo

K. Barabás, É M. Szegõ, A. Kaszás, G. M. Nagy, G. Juhász, I. M. Ábrahám

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In addition to the classical direct genomic mechanisms of action, oestrogen also exerts poorly understood, nonclassical effects on the signalling system in neurones. In the present study, we investigated whether sex differences exist in gonadectomy- and oestrogen-induced effects on p44/42 mitogen-activated protein kinase (MAPK) phosphorylation in specific brain regions of mice. We demonstrate that MAPK immunoreactivity was not altered by gonadectomy or oestrogen treatment in either sex. However, we show that the level of phosphorylated MAPK (pMAPK) within the anteroventral periventricular nucleus (AVPV) was consistently higher in males than females irrespective of gonadal steroid hormone status. In addition, gonadectomy was found to decrease pMAPK immunoreactivity within the piriform cortex of males. Oestrogen increased pMAPK immunoreactivity in the medial preoptic area and AVPV of females, but failed to have the same effect in male mice. Overall, these results demonstrate a marked sex difference in oestrogen-induced alteration of MAPK phosphorylation in the brain in vivo.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalJournal of Neuroendocrinology
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Mitogen-Activated Protein Kinases
Sex Characteristics
Estrogens
Phosphorylation
Brain
Anterior Hypothalamus
Preoptic Area
Gonadal Steroid Hormones
Neurons

Keywords

  • Gonadectomy
  • MAPK phosphorylation
  • Oestrogen
  • Sex differences

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Sex differences in oestrogen-induced p44/42 MAPK phosphorylation in mouse brain in vivo. / Barabás, K.; Szegõ, É M.; Kaszás, A.; Nagy, G. M.; Juhász, G.; Ábrahám, I. M.

In: Journal of Neuroendocrinology, Vol. 18, No. 8, 08.2006, p. 621-628.

Research output: Contribution to journalArticle

Barabás, K. ; Szegõ, É M. ; Kaszás, A. ; Nagy, G. M. ; Juhász, G. ; Ábrahám, I. M. / Sex differences in oestrogen-induced p44/42 MAPK phosphorylation in mouse brain in vivo. In: Journal of Neuroendocrinology. 2006 ; Vol. 18, No. 8. pp. 621-628.
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