Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model

A. Oláh, Csaba Mátyás, Dalma Kellermayer, Mihály Ruppert, Bálint András Barta, Alex Ali Sayour, Marianna Török, Gábor Koncsos, Zoltáng Giricz, Péter Ferdinandy, B. Merkely, T. Radovits

Research output: Contribution to journalArticle

Abstract

Background: Recent evidences suggest that sex hormones may be involved in the regulation of exercise-induced left ventricular (LV) hypertrophy. However, the sex-specific functional consequences of exercise-induced myocardial hypertrophy is still not investigated in detail. We aimed at understanding the sex-specific functional and morphological alterations in the LV and the underlying molecular changes in a rat model of athlete's heart. Methods: We divided our young, adult male and female rats into control and exercised groups. Athlete's heart was induced by a 12-week long swim training. Following the training period, we assessed LV hypertrophy with echocardiography, while pressure-volume analysis was performed to investigate in vivo LV function. After in vivo experiments, molecular biological studies and histological investigations were performed. Results: Echocardiography and post-mortem measured heart weight data indicated LV hypertrophy in both genders, nevertheless it was more pronounced in females. Despite the more significant relative hypertrophy in females, characteristic functional parameters did not show notable differences between the genders. LV pressure-volume analysis showed increased stroke volume, improved contractility and stroke work and unaltered LV stiffness in both male and female exercised rats, while active relaxation was ameliorated solely in male animals. The induction of Akt signaling was more significant in females compared to males. There was also a characteristic difference in the mitogen-activated protein kinase pathway as suppressed phosphorylation of p44/42 MAPK (Erk) and mTOR was observed in female exercised rats, but not in male ones. Myosin heavy chain α (MHC)/β-MHC ratio did not differ in males, but increased markedly in females. Conclusion: Our results confirm that there is a more pronounced exercise-induced LV hypertrophy in females as compared to the males, however, there are only minor differences regarding LV function. There are characteristic molecular differences between male and female animals, that can explain different degrees of LV hypertrophy.

Original languageEnglish
Article number889
JournalFrontiers in Physiology
Volume10
Issue numberJUL
DOIs
Publication statusPublished - Jan 1 2019

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Cardiomegaly
Sex Characteristics
Exercise
Left Ventricular Hypertrophy
Myosin Heavy Chains
Left Ventricular Function
Athletes
Hypertrophy
Echocardiography
Mitogen-Activated Protein Kinase 3
Gonadal Steroid Hormones
Ventricular Pressure
Mitogen-Activated Protein Kinases
Stroke Volume
Young Adult
Stroke
Phosphorylation
Pressure
Weights and Measures
Control Groups

Keywords

  • Athlete's heart
  • Exercise-induced hypertrophy
  • Left ventricular function
  • Pressure-volume analysis
  • Sex differences

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model. / Oláh, A.; Mátyás, Csaba; Kellermayer, Dalma; Ruppert, Mihály; Barta, Bálint András; Sayour, Alex Ali; Török, Marianna; Koncsos, Gábor; Giricz, Zoltáng; Ferdinandy, Péter; Merkely, B.; Radovits, T.

In: Frontiers in Physiology, Vol. 10, No. JUL, 889, 01.01.2019.

Research output: Contribution to journalArticle

Oláh, A, Mátyás, C, Kellermayer, D, Ruppert, M, Barta, BA, Sayour, AA, Török, M, Koncsos, G, Giricz, Z, Ferdinandy, P, Merkely, B & Radovits, T 2019, 'Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model', Frontiers in Physiology, vol. 10, no. JUL, 889. https://doi.org/10.3389/fphys.2019.00889
Oláh, A. ; Mátyás, Csaba ; Kellermayer, Dalma ; Ruppert, Mihály ; Barta, Bálint András ; Sayour, Alex Ali ; Török, Marianna ; Koncsos, Gábor ; Giricz, Zoltáng ; Ferdinandy, Péter ; Merkely, B. ; Radovits, T. / Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model. In: Frontiers in Physiology. 2019 ; Vol. 10, No. JUL.
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AU - Mátyás, Csaba

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AU - Barta, Bálint András

AU - Sayour, Alex Ali

AU - Török, Marianna

AU - Koncsos, Gábor

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