Sex-dependent survival of rats after bilateral pallidal lesions

L. Lénárd, Janna Sarkisian, I. Szabó

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of unilateral and bilateral pallidal lesions were studied in male and female rats. While unilateral lesions produced only transient aphagia and adipsia, the results of bilateral lesions were more severe. Sixteen out of 30 rats of the Wistar strain survived the bilateral lesion and the survivors were followed until the 157th day. The majority of survivors were females. The recovery of males was slower than females. All the surviving animals and also some of those which died ate and drank spontaneously. Similar results were obtained in repeated experiment on the CFY strain of rats. Our data suggest that aphagia and adipsia, as well as the considerable weight loss causing the death of animals may be regarded as disorders of two partially independent mechanisms; however, both of them are expressed more in male than female animals.

Original languageEnglish
Pages (from-to)389-397
Number of pages9
JournalPhysiology and Behavior
Volume15
Issue number4
DOIs
Publication statusPublished - 1975

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Wistar Rats
Weight Loss

Keywords

  • Body weight changes
  • Consumption
  • Hypothalamic degeneration
  • Pallidal aphagia and adipsia
  • Recovery
  • Sex-dependent survival
  • Weight loss and death

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Sex-dependent survival of rats after bilateral pallidal lesions. / Lénárd, L.; Sarkisian, Janna; Szabó, I.

In: Physiology and Behavior, Vol. 15, No. 4, 1975, p. 389-397.

Research output: Contribution to journalArticle

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