Sex-dependent consequences of bilateral pallidal lesion after postpuberal castration in rats

Z. Hahn, L. Lenard

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3 Citations (Scopus)


Consequences (aphagia, adipsia, body weight loss, postoperative mortality) of bilateral pallidal lesion are sex-dependent, all of them being more severe in males than in females. Castration prior to lesion failed to eliminate the sex-dependence. Artificial food and water administration was ineffective in abolishing the difference in body weight changes between males and females. Body weight of females did not exceed their preoperative weight even 90 days after lesion. A close positive correlation was found in females between weight on the 90th postoperative day and the lowest body weight in the first 14 days after lesion. Vaginal cycles of non-castrated females were normal between the 75th and 87th postoperative days. Sex-dependent activity of a metabolic factor independent of postpuberal sexual steroid levels may be responsible for the effect.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalActa physiologica Academiae Scientiarum Hungaricae
Issue number1
Publication statusPublished - Jan 1 1977


ASJC Scopus subject areas

  • Physiology

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